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- W2952720799 abstract "The modulation of pro-inflammatory cytokines provides a target for controlling inflammatory diseases and attracts much attention in current anti-inflammatory drug development. Here, four series of thiazolidinone derivatives were synthesized and screened for anti-inflammatory activities. A majority of these compounds showed excellent inhibition on the expression of TNF-α and IL-6 in LPS-stimulated macrophages. Discussions are given regarding the structure–activity relationships. Compounds 12d and 12h inhibited LPS-induced TNF-α and IL-6 release in a dose-dependent manner. Furthermore, 12d exhibited a significant protection against LPS-induced septic death in mouse model. Together, these data present a series of new thiazolidinones with potential therapeutic effects in acute inflammatory diseases and they could be important leads in the continuing anti-inflammatory drug research." @default.
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- W2952720799 date "2013-06-01" @default.
- W2952720799 modified "2023-10-09" @default.
- W2952720799 title "Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents" @default.
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- W2952720799 doi "https://doi.org/10.1016/j.ejmech.2013.04.010" @default.
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