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• W2952809716 abstract "Our previous studies revealed a novel mechanism for lipid droplet (LD)-mediated ER proteostasis that is stimulated by lipid imbalance-induced ER stress. They support the model that this stressor stimulates removal of proteins from the ER by LDs and degradation of LDs by microlipophagy, autophagosome-independent LD uptake into the vacuole (the yeast lysosome). Here, we show that a similar mechanism occurs during dithiothreitol (DTT)- or tunicamycin (TM)-induced ER stress. We identified proteins that are possible targets for LD-mediated ER proteostasis and find that the targets vary in response to different ER stressors. Our live-cell imaging studies provide the first direct evidence that one of these targets (Nup159p) can be removed from ER membranes by LDs, moves with LDs through the cytosol and co-localizes with LDs in the vacuolar lumen. Thus, we obtained the first direct evidence that LDs can mediate ER proteostasis. Microlipophagy induced by all stressors studied does not require core ATG genes and can occur in the absence of liquid-ordered microdomains (Lo) in the vacuolar membrane. Instead, we find that the endosome sorting complexes required for transport (ESCRT) I-III are up-regulated, recruited to vacuolar membranes, and required for microlipophagy in response to all ER stressors analyzed. Interestingly, ESCRT 0 is not required for DTT-induced microlipophagy but is required for microlipophagy induced by other stressors studied. Our imaging studies also revealed an unexpected role for vacuolar fusion in remodeling and invagination of the vacuolar membrane during microlipophagy." @default.
• W2952809716 created "2019-06-27" @default.
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• W2952809716 date "2019-01-01" @default.
• W2952809716 modified "2023-09-28" @default.
• W2952809716 title "Membrane Dynamics of Lipid Droplet-Mediated ER Proteostasis in the Budding Yeast, <i>Saccharomyces cerevisiae</i>" @default.
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• W2952809716 doi "https://doi.org/10.2139/ssrn.3401844" @default.
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