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- W2953260725 abstract "Proteins are the functional molecules in organisms and are therefore excellent biomarker candidates for a diversity of diseases. Immunoassays and mass spectrometry (MS) are two major technologies being used in proteomics; however, they either lack specificity or sensitivity. An emerging trend is to combine immunoassays with MS (which we call “affinity-MS”). This is an important milestone in quantitative proteomics, making it possible to measure low-abundance proteins with high specificity. The targeted enrichment and the assignment of mass-to-charge ratios to different molecules provide two selection criteria, making affinity-MS highly specific. Picogram-per-milliliter limits of detection have been obtained for many proteins. Furthermore, multiplexing capacity of >150 proteins has been achieved. This article reviews different formats of affinity-enrichment methods, and demonstrates how they are interfaced with both electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) MS. The pros and cons of these techniques are compared, and future prospectives are discussed." @default.
- W2953260725 created "2019-06-27" @default.
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- W2953260725 creator A5048101735 @default.
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- W2953260725 date "2017-05-01" @default.
- W2953260725 modified "2023-10-14" @default.
- W2953260725 title "Affinity-mass spectrometric technologies for quantitative proteomics in biological fluids" @default.
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- W2953260725 doi "https://doi.org/10.1016/j.trac.2017.02.011" @default.
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