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- W2954877960 abstract "Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia‐reperfusion injuries. After the initial hypoxic‐ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune response in pathophysiological characteristics and recovery is not well understood. We studied immune cell activity and its association with outcomes in a cohort of CA survivors. Methods and Results After informed consent, we collected blood samples at intervals over a week after resuscitation from CA . We examined the expression of CD 39 and CD 73 (alias 5′‐nucleotidase), production of tumor necrosis factor‐α, generation of reactive oxygen species, and secretion of vascular endothelial growth factor by circulating myeloid and lymphoid cells, in comparison to cells obtained from control subjects before coronary artery bypass grafting surgery. The number of circulating total and CD 73‐expressing lymphocytes correlated with survival after CA . Incubation of immune cells, obtained from post‐ CA subjects, with AMP , a substrate for CD 73, resulted in inhibition of tumor necrosis factor‐α production and generation of reactive oxygen species. This effect was blocked by adenosine 5′‐(α, β‐methylene) diphosphate, a specific inhibitor of CD 73 and ZM 241385, an A2 adenosine receptor antagonist. We also found that AMP ‐dependent activation of CD 73 induces production of vascular endothelial growth factor. Conclusions CD 73‐expressing lymphocytes mediate cellular protection from inflammation after CA through inhibition of proinflammatory activation of myeloid cells and promotion of vascular endothelial growth factor secretion. The contribution of CD 73 lymphocytes in the regulation of acute inflammation and tissue injury after CA warrants further study." @default.
- W2954877960 created "2019-07-12" @default.
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- W2954877960 date "2019-07-02" @default.
- W2954877960 modified "2023-10-18" @default.
- W2954877960 title "Number of Circulating CD73‐Expressing Lymphocytes Correlates With Survival After Cardiac Arrest" @default.
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- W2954877960 cites W1858171089 @default.
- W2954877960 cites W1964851502 @default.
- W2954877960 cites W1970277597 @default.
- W2954877960 cites W1978007256 @default.
- W2954877960 cites W1984077726 @default.
- W2954877960 cites W1984747276 @default.
- W2954877960 cites W1990479642 @default.
- W2954877960 cites W1997406930 @default.
- W2954877960 cites W2001776200 @default.
- W2954877960 cites W2010484516 @default.
- W2954877960 cites W2010731637 @default.
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- W2954877960 cites W2031462278 @default.
- W2954877960 cites W2039217013 @default.
- W2954877960 cites W2057413381 @default.
- W2954877960 cites W2062922526 @default.
- W2954877960 cites W2073054137 @default.
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- W2954877960 cites W2099143798 @default.
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- W2954877960 cites W2135255941 @default.
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- W2954877960 doi "https://doi.org/10.1161/jaha.118.010874" @default.
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