FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956052367> ?p ?o ?g. }

• W2956052367 endingPage "5531" @default.
• W2956052367 startingPage "5518" @default.
• W2956052367 abstract "Abstract Glioma is the most common primary intracranial carcinoma with extremely poor prognosis. The significances of long non‐coding RNA (lncRNA) involved in glioma have been started revealed. However, the expression, roles and molecular mechanisms of most lncRNAs in glioma are still unknown. In this study, we identified a novel lncRNA LINC00526, which is significantly low expressed in glioma. Low expression of LINC00526 is correlated with aggravation and poor survival in glioma. Functional assays revealed that ectopic expression of LINC00526 inhibits glioma cell proliferation, migration, and invasion. LINC00526 silencing promotes glioma cell proliferation, migration and invasion. Mechanistically, we found that LINC00526 directly interacts with EZH2, represses the binding of EZH2 to AXL promoter, attenuates the transcriptional activating roles of EZH2 on AXL , and therefore represses AXL expression. Via repressing AXL, LINC00526 further represses PI3K/Akt/NF‐κB signalling. Intriguingly, we identified that NFKB1 and NFKB2 directly binds LINC00526 promoter and represses LINC00526 transcription. We further found that via activating NF‐κB signalling, AXL represses LINC00526 transcription. Therefore, LINC00526/EZH2/AXL/PI3K/Akt/NF‐κB form a feedback loop in glioma. Analysis of the TCGA data revealed that the expression of LINC00526 is inversely correlated with that of AXL in glioma tissues. In addition, functional rescue assays revealed that the tumour suppressive roles of LINC00526 are dependent on the negative regulation of AXL. Collectively, our data identified LINC00526 as a tumour suppressor in glioma via forming a double negative feedback loop with AXL. Our data also suggested LINC00526 as a potential prognostic biomarker and therapeutic candidate for glioma." @default.
• W2956052367 created "2019-07-12" @default.
• W2956052367 creator A5011023244 @default.
• W2956052367 creator A5017635214 @default.
• W2956052367 creator A5018241330 @default.
• W2956052367 creator A5026108587 @default.
• W2956052367 creator A5042945387 @default.
• W2956052367 creator A5058277778 @default.
• W2956052367 creator A5074588368 @default.
• W2956052367 date "2019-06-26" @default.
• W2956052367 modified "2023-09-30" @default.
• W2956052367 title "Long non‐coding RNA LINC00526 represses glioma progression via forming a double negative feedback loop with AXL" @default.
• W2956052367 cites W1817643805 @default.
• W2956052367 cites W1993574813 @default.
• W2956052367 cites W2029919331 @default.
• W2956052367 cites W2036044314 @default.
• W2956052367 cites W2068517905 @default.
• W2956052367 cites W2088680545 @default.
• W2956052367 cites W2091161969 @default.
• W2956052367 cites W2098341282 @default.
• W2956052367 cites W2106382644 @default.
• W2956052367 cites W2117716725 @default.
• W2956052367 cites W2130543801 @default.
• W2956052367 cites W2144137532 @default.
• W2956052367 cites W2153882021 @default.
• W2956052367 cites W2167226090 @default.
• W2956052367 cites W2289087411 @default.
• W2956052367 cites W2335029242 @default.
• W2956052367 cites W2508545091 @default.
• W2956052367 cites W2591074529 @default.
• W2956052367 cites W2618859545 @default.
• W2956052367 cites W2626028212 @default.
• W2956052367 cites W2659568498 @default.
• W2956052367 cites W2659689178 @default.
• W2956052367 cites W2729868770 @default.
• W2956052367 cites W2742004158 @default.
• W2956052367 cites W2746147763 @default.
• W2956052367 cites W2767543713 @default.
• W2956052367 cites W2770178180 @default.
• W2956052367 cites W2771049305 @default.
• W2956052367 cites W2782959626 @default.
• W2956052367 cites W2787851539 @default.
• W2956052367 cites W2789269408 @default.
• W2956052367 cites W2789387026 @default.
• W2956052367 cites W2789926271 @default.
• W2956052367 cites W2793711924 @default.
• W2956052367 cites W2795075229 @default.
• W2956052367 cites W2795382323 @default.
• W2956052367 cites W2795441251 @default.
• W2956052367 cites W2796179714 @default.
• W2956052367 cites W2796558260 @default.
• W2956052367 cites W2796861734 @default.
• W2956052367 cites W2807003152 @default.
• W2956052367 cites W2808668766 @default.
• W2956052367 cites W2809813113 @default.
• W2956052367 cites W2883978878 @default.
• W2956052367 cites W2885561478 @default.
• W2956052367 cites W2887853695 @default.
• W2956052367 cites W2892016022 @default.
• W2956052367 cites W2895052500 @default.
• W2956052367 cites W2899424575 @default.
• W2956052367 cites W2900938974 @default.
• W2956052367 cites W2904508384 @default.
• W2956052367 cites W2905497924 @default.
• W2956052367 cites W2905569206 @default.
• W2956052367 cites W2907733233 @default.
• W2956052367 cites W2916484172 @default.
• W2956052367 doi "https://doi.org/10.1111/jcmm.14435" @default.
• W2956052367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6653591" @default.
• W2956052367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31240814" @default.
• W2956052367 hasPublicationYear "2019" @default.
• W2956052367 type Work @default.
• W2956052367 sameAs 2956052367 @default.
• W2956052367 citedByCount "12" @default.
• W2956052367 countsByYear W29560523672019 @default.
• W2956052367 countsByYear W29560523672020 @default.
• W2956052367 countsByYear W29560523672021 @default.
• W2956052367 countsByYear W29560523672022 @default.
• W2956052367 countsByYear W29560523672023 @default.
• W2956052367 crossrefType "journal-article" @default.
• W2956052367 hasAuthorship W2956052367A5011023244 @default.
• W2956052367 hasAuthorship W2956052367A5017635214 @default.
• W2956052367 hasAuthorship W2956052367A5018241330 @default.
• W2956052367 hasAuthorship W2956052367A5026108587 @default.
• W2956052367 hasAuthorship W2956052367A5042945387 @default.
• W2956052367 hasAuthorship W2956052367A5058277778 @default.
• W2956052367 hasAuthorship W2956052367A5074588368 @default.
• W2956052367 hasBestOaLocation W29560523671 @default.
• W2956052367 hasConcept C104317684 @default.
• W2956052367 hasConcept C119056186 @default.
• W2956052367 hasConcept C138885662 @default.
• W2956052367 hasConcept C150194340 @default.
• W2956052367 hasConcept C179926584 @default.
• W2956052367 hasConcept C2778227246 @default.
• W2956052367 hasConcept C41895202 @default.
• W2956052367 hasConcept C50171091 @default.
• W2956052367 hasConcept C502942594 @default.
• W2956052367 hasConcept C54355233 @default.

• next