FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2956434797> ?p ?o ?g. }

• W2956434797 endingPage "110365" @default.
• W2956434797 startingPage "110365" @default.
• W2956434797 abstract "Stimuli-responsive polymeric nanogels have been proposed as nanocarriers of cisplatin to maximize its effect for cancer treatment. In this work, a comparative study between anionic core nanogels (ACN) and cationic core nanogels (CCN), both with PEGylated shells, has been performed. The nanogels were synthesized with different cross-linked cores: CCN with poly(N,N-diethylaminoethyl methacrylate) (PDEAEMA) and ACN with poly(2-methacryloyloxi benzoic acid) (P2MBA). Cisplatin chelate formation with carboxylic acids (ACN) or metal coordination with the amine groups (CCN) leads to a high loading of cisplatin into the nanocarriers. The nanocarriers ability to contain and modulate the supply of cisplatin was tested according to the pH of the medium, in which ACN efficiently released the drug at a typical pH value of a tumor tissue (pH = 6.8) while CCN only releases the drug at more acidic, endosome like, conditions (pH = 5). The effect of drug-free nanogels on cell lines NCI-H1437 (non-small cell lung carcinoma) was evaluated, showing biocompatibility at all concentrations studied (30–400 μg/mL) for both ACN and CCN. However, the survival percentage of the cells in contact with cisplatin-loaded nanogels were dependent on the dose, the time of contact and the type of nanogel. Cisplatin loaded CCN induced lower cell viability after 48 h of contact. Fluorescence microscopy showed a viable internalization of the CCN nanogels, this was confirmed by flow cytometry in which 37.8% of cells contained drug loaded CCNs after 30 min of contact, representing a more effective nanocarrier for cisplatin to this cell-line." @default.
• W2956434797 created "2019-07-23" @default.
• W2956434797 creator A5033336380 @default.
• W2956434797 creator A5033948065 @default.
• W2956434797 creator A5042467889 @default.
• W2956434797 creator A5047242952 @default.
• W2956434797 creator A5050904016 @default.
• W2956434797 creator A5051263414 @default.
• W2956434797 date "2019-10-01" @default.
• W2956434797 modified "2023-10-18" @default.
• W2956434797 title "Cationic versus anionic core-shell nanogels for transport of cisplatin to lung cancer cells" @default.
• W2956434797 cites W1534849470 @default.
• W2956434797 cites W1978649563 @default.
• W2956434797 cites W1990621588 @default.
• W2956434797 cites W1997581567 @default.
• W2956434797 cites W2007799168 @default.
• W2956434797 cites W2011030869 @default.
• W2956434797 cites W2027876233 @default.
• W2956434797 cites W2040042243 @default.
• W2956434797 cites W2044813154 @default.
• W2956434797 cites W2051187762 @default.
• W2956434797 cites W2051609383 @default.
• W2956434797 cites W2054745605 @default.
• W2956434797 cites W2065829759 @default.
• W2956434797 cites W2070912023 @default.
• W2956434797 cites W2074860227 @default.
• W2956434797 cites W2078057254 @default.
• W2956434797 cites W2079126602 @default.
• W2956434797 cites W2085153421 @default.
• W2956434797 cites W2087431312 @default.
• W2956434797 cites W2110954157 @default.
• W2956434797 cites W2127618819 @default.
• W2956434797 cites W2129360146 @default.
• W2956434797 cites W2150918607 @default.
• W2956434797 cites W2154824806 @default.
• W2956434797 cites W2155764563 @default.
• W2956434797 cites W2161279046 @default.
• W2956434797 cites W2163818897 @default.
• W2956434797 cites W2197718265 @default.
• W2956434797 cites W2256521570 @default.
• W2956434797 cites W2301722455 @default.
• W2956434797 cites W2313811022 @default.
• W2956434797 cites W2325736328 @default.
• W2956434797 cites W2326135482 @default.
• W2956434797 cites W2549873556 @default.
• W2956434797 cites W2594622216 @default.
• W2956434797 cites W2605278786 @default.
• W2956434797 cites W2612510278 @default.
• W2956434797 cites W2730656730 @default.
• W2956434797 cites W2740639997 @default.
• W2956434797 cites W2749866662 @default.
• W2956434797 cites W2766534311 @default.
• W2956434797 cites W2768512267 @default.
• W2956434797 cites W2805878679 @default.
• W2956434797 cites W2895123715 @default.
• W2956434797 cites W57956218 @default.
• W2956434797 cites W634614115 @default.
• W2956434797 cites W2757757083 @default.
• W2956434797 doi "https://doi.org/10.1016/j.colsurfb.2019.110365" @default.
• W2956434797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31344612" @default.
• W2956434797 hasPublicationYear "2019" @default.
• W2956434797 type Work @default.
• W2956434797 sameAs 2956434797 @default.
• W2956434797 citedByCount "16" @default.
• W2956434797 countsByYear W29564347972020 @default.
• W2956434797 countsByYear W29564347972021 @default.
• W2956434797 countsByYear W29564347972022 @default.
• W2956434797 countsByYear W29564347972023 @default.
• W2956434797 crossrefType "journal-article" @default.
• W2956434797 hasAuthorship W2956434797A5033336380 @default.
• W2956434797 hasAuthorship W2956434797A5033948065 @default.
• W2956434797 hasAuthorship W2956434797A5042467889 @default.
• W2956434797 hasAuthorship W2956434797A5047242952 @default.
• W2956434797 hasAuthorship W2956434797A5050904016 @default.
• W2956434797 hasAuthorship W2956434797A5051263414 @default.
• W2956434797 hasConcept C12554922 @default.
• W2956434797 hasConcept C134424308 @default.
• W2956434797 hasConcept C13965031 @default.
• W2956434797 hasConcept C141071460 @default.
• W2956434797 hasConcept C178790620 @default.
• W2956434797 hasConcept C18150654 @default.
• W2956434797 hasConcept C185592680 @default.
• W2956434797 hasConcept C2776694085 @default.
• W2956434797 hasConcept C2777230088 @default.
• W2956434797 hasConcept C2778239845 @default.
• W2956434797 hasConcept C2779820397 @default.
• W2956434797 hasConcept C71924100 @default.
• W2956434797 hasConcept C86803240 @default.
• W2956434797 hasConceptScore W2956434797C12554922 @default.
• W2956434797 hasConceptScore W2956434797C134424308 @default.
• W2956434797 hasConceptScore W2956434797C13965031 @default.
• W2956434797 hasConceptScore W2956434797C141071460 @default.
• W2956434797 hasConceptScore W2956434797C178790620 @default.
• W2956434797 hasConceptScore W2956434797C18150654 @default.
• W2956434797 hasConceptScore W2956434797C185592680 @default.
• W2956434797 hasConceptScore W2956434797C2776694085 @default.
• W2956434797 hasConceptScore W2956434797C2777230088 @default.
• W2956434797 hasConceptScore W2956434797C2778239845 @default.

• next