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• W2963125412 abstract "Abstract Background Oral squamous cell carcinoma is the eighth most common cancer worldwide with a relatively high rate of metastasis (~40%). Previously, we showed that microRNA‐138 serves as a functional tumor suppressor and plays an important role in oral squamous cell carcinoma metastasis. However, to date, microRNA‐138 expression has not been examined in this tumor tissue. Herein, we demonstrated that microRNA‐138 expression is downregulated in metastatic oral squamous cell carcinoma specimens using tissue microarray technology with in situ hybridization. Methods The study included 254 oral squamous cell carcinoma patients from two centers (160 from the Chengdu center and 90 from the Guangzhou center) and four healthy volunteers. Results Multivariate analysis showed that microRNA‐138 expression was independent of tumor stage, age, gender, smoking, and alcohol consumption in oral squamous cell carcinoma patients. Interestingly, patients that expressed lower levels of microRNA‐138 (determined by in situ hybridization) were more prone to regional lymph node metastasis and exhibited poorer outcomes. These findings support the role of microRNA‐138 as a tumor suppressor in oral squamous cell carcinoma. Conclusion In summary, the expression level of microRNA‐138 is negatively correlated with oral squamous cell carcinoma metastasis; the lower the expression of microRNA‐138, the higher the rate of metastasis and the poorer the prognosis of the patients. Therefore, our study confirms that microRNA‐138 serves as a tumor suppressor and plays a functional role in oral squamous cell carcinoma tumor metastasis; microRNA‐138 constitutes a promising prognosis biomarker and therapeutic target for oral squamous cell carcinoma with metastasis potential." @default.
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• W2963125412 date "2019-08-11" @default.
• W2963125412 modified "2023-10-14" @default.
• W2963125412 title "In situ measurement of miR‐138 expression in oral squamous cell carcinoma tissue supports the role of this microRNA as a tumor suppressor" @default.
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• W2963125412 doi "https://doi.org/10.1111/jop.12933" @default.
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