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• W2968761786 endingPage "11128" @default.
• W2968761786 startingPage "11122" @default.
• W2968761786 abstract "Accurate quantifications of cellular miRNAs are important not only for accelerating them becoming reliable diagnostics biomarkers but also for deeply understanding their influence on central signaling pathways. Although single-molecule miRNA imaging permits quantifying biomolecules at the single-molecule level, it is limited by the sensitivity and specificity of hybridization-based probes. We report a miRNA single-molecule imaging method by using conjugated polymer nanoparticle (CPN) labeled short DNA probe termed as a nanoflare. The transient hybridization of the nanoflares and target miRNAs yields a featured single-molecule kinetics signal rendering high single-molecule sensitivity and specificity. miRNA can be detected with a remarkable detection limit of 1 fM without using any amplification steps. The discrimination capability of homologous miRNAs was also demonstrated. Taking advantage of the featured single-molecule signal of the nanoflare, we can directly count single miR-21 molecules in single cells by using highly inclined and laminated optical sheet (HILO) microscopy. The statistics of the counting reveals miR-21’s cell-to-cell fluctuation and differential expression of tumor cells and normal cells." @default.
• W2968761786 created "2019-08-22" @default.
• W2968761786 creator A5000248128 @default.
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• W2968761786 date "2019-08-12" @default.
• W2968761786 modified "2023-10-12" @default.
• W2968761786 title "Transient Hybridization Directed Nanoflare for Single-Molecule miRNA Imaging" @default.
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• W2968761786 doi "https://doi.org/10.1021/acs.analchem.9b01766" @default.
• W2968761786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31402644" @default.
• W2968761786 hasPublicationYear "2019" @default.
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