FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970297839> ?p ?o ?g. }

• W2970297839 endingPage "9402" @default.
• W2970297839 startingPage "9396" @default.
• W2970297839 abstract "7-Fluoro-2-aminophenazine 5,10-dioxide, 1, has displayed in vitro bioreductive selective cytotoxicity, which could acts towards tumors containing hypoxic regions. In this work, we describe some preclinical studies of compound 1 confirming its in vivo antitumor activity. The synthesis of compound 1 was scaled up to 3 g improving the micro-scale yield. Some drug-like properties for compound 1 were theoretically-predicted and others, i. e. aqueous-solubility and toxicity -mutagenicity, in vivo chromosomal-aberrations and ip acute LD50-, were experimentally confirmed. Antitumoral activity was studied in mice bearing hypoxic 4T1-breast-tumor by assessing evolution of the tumor-sizes, animal-survival and bio-chemical/hematological. Compound 1 in vivo efficacy, with the absence of systemic toxicity, was confirmed.. Results highlight the potential of 7-fluoro-2-aminophenazine 5,10-dioxide as promissory therapeutic agent for solid tumors." @default.
• W2970297839 created "2019-09-05" @default.
• W2970297839 creator A5002231168 @default.
• W2970297839 creator A5009895617 @default.
• W2970297839 creator A5024816595 @default.
• W2970297839 creator A5049255660 @default.
• W2970297839 creator A5070353911 @default.
• W2970297839 creator A5080927889 @default.
• W2970297839 creator A5087934284 @default.
• W2970297839 creator A5090432365 @default.
• W2970297839 date "2019-08-27" @default.
• W2970297839 modified "2023-10-06" @default.
• W2970297839 title "Selective Hypoxia‐Cytotoxin 7‐Fluoro‐2‐Aminophenazine 5,10‐Dioxide: Toward “Candidate‐to‐Drug” Stage in the Drug‐Development Pipeline" @default.
• W2970297839 cites W1506008586 @default.
• W2970297839 cites W1565164189 @default.
• W2970297839 cites W1964426728 @default.
• W2970297839 cites W1971574764 @default.
• W2970297839 cites W1971606784 @default.
• W2970297839 cites W1972676827 @default.
• W2970297839 cites W1975633055 @default.
• W2970297839 cites W1979970332 @default.
• W2970297839 cites W1986024777 @default.
• W2970297839 cites W1993323132 @default.
• W2970297839 cites W2008517609 @default.
• W2970297839 cites W2010163063 @default.
• W2970297839 cites W2012444866 @default.
• W2970297839 cites W2013645558 @default.
• W2970297839 cites W2014110208 @default.
• W2970297839 cites W2014858249 @default.
• W2970297839 cites W2016286462 @default.
• W2970297839 cites W2026813111 @default.
• W2970297839 cites W2031449719 @default.
• W2970297839 cites W2036846365 @default.
• W2970297839 cites W2037385269 @default.
• W2970297839 cites W2040651998 @default.
• W2970297839 cites W2046881237 @default.
• W2970297839 cites W2051387214 @default.
• W2970297839 cites W2054203041 @default.
• W2970297839 cites W2054934813 @default.
• W2970297839 cites W2068879317 @default.
• W2970297839 cites W2074176940 @default.
• W2970297839 cites W2094633478 @default.
• W2970297839 cites W2121929569 @default.
• W2970297839 cites W2132149333 @default.
• W2970297839 cites W2142633038 @default.
• W2970297839 cites W2154346931 @default.
• W2970297839 cites W2155780470 @default.
• W2970297839 cites W2255357451 @default.
• W2970297839 cites W2526429481 @default.
• W2970297839 cites W2568720956 @default.
• W2970297839 cites W2586840087 @default.
• W2970297839 cites W2587923620 @default.
• W2970297839 cites W2727479841 @default.
• W2970297839 cites W2773131117 @default.
• W2970297839 cites W2795990497 @default.
• W2970297839 cites W2894918092 @default.
• W2970297839 cites W2905240006 @default.
• W2970297839 cites W2950703672 @default.
• W2970297839 cites W4248819034 @default.
• W2970297839 doi "https://doi.org/10.1002/slct.201902601" @default.
• W2970297839 hasPublicationYear "2019" @default.
• W2970297839 type Work @default.
• W2970297839 sameAs 2970297839 @default.
• W2970297839 citedByCount "4" @default.
• W2970297839 countsByYear W29702978392020 @default.
• W2970297839 countsByYear W29702978392021 @default.
• W2970297839 countsByYear W29702978392022 @default.
• W2970297839 crossrefType "journal-article" @default.
• W2970297839 hasAuthorship W2970297839A5002231168 @default.
• W2970297839 hasAuthorship W2970297839A5009895617 @default.
• W2970297839 hasAuthorship W2970297839A5024816595 @default.
• W2970297839 hasAuthorship W2970297839A5049255660 @default.
• W2970297839 hasAuthorship W2970297839A5070353911 @default.
• W2970297839 hasAuthorship W2970297839A5080927889 @default.
• W2970297839 hasAuthorship W2970297839A5087934284 @default.
• W2970297839 hasAuthorship W2970297839A5090432365 @default.
• W2970297839 hasConcept C109316439 @default.
• W2970297839 hasConcept C150903083 @default.
• W2970297839 hasConcept C178790620 @default.
• W2970297839 hasConcept C185592680 @default.
• W2970297839 hasConcept C202751555 @default.
• W2970297839 hasConcept C207001950 @default.
• W2970297839 hasConcept C2780035454 @default.
• W2970297839 hasConcept C29730261 @default.
• W2970297839 hasConcept C540031477 @default.
• W2970297839 hasConcept C55493867 @default.
• W2970297839 hasConcept C71924100 @default.
• W2970297839 hasConcept C7836513 @default.
• W2970297839 hasConcept C86803240 @default.
• W2970297839 hasConcept C98274493 @default.
• W2970297839 hasConceptScore W2970297839C109316439 @default.
• W2970297839 hasConceptScore W2970297839C150903083 @default.
• W2970297839 hasConceptScore W2970297839C178790620 @default.
• W2970297839 hasConceptScore W2970297839C185592680 @default.
• W2970297839 hasConceptScore W2970297839C202751555 @default.
• W2970297839 hasConceptScore W2970297839C207001950 @default.
• W2970297839 hasConceptScore W2970297839C2780035454 @default.
• W2970297839 hasConceptScore W2970297839C29730261 @default.

• next