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• W2973154258 endingPage "111611" @default.
• W2973154258 startingPage "111611" @default.
• W2973154258 abstract "In search for improvements in bioanalysis electrochemical sensors, for better assessment of anti-cancer drugs, it is necessary for their detection limits to be minimized and the sensitivity and selectivity to be surpassed simultaneously; whereas, resolving any probable interfering with other medical treatments are considered. In this work, a novel approach was adopted for detection and assessment of Gemcitabine (GEM) as an anti-cancer drug based on evaluating its interaction with EGFR exon 21-point mutant gene. An electrochemical nanobiosensor was invented based on a new molecularly bioimprinted siloxane polymer (MBIS) strategy; in which the EGFR exon 21 acts as an identification probe. The roles of multi-walled carbon nanotubes and Ag nanoparticles (NPs) are to perform as a signal amplifier. The MBIS film was prepared by acid-catalysed hydrolysis/condensation of the sample solution, containing Ag NPs, ds-DNA of EGFR exon 21 point mutant gene, GEM as a template molecule, 3-(aminopropyl) trimethoxysilane (APTMS) and tetraethoxysilane. The interaction between the dsDNA and GEM was investigated by employing the modified biosensor and monitoring oxidation signal of guanine and adenine. The produced biosensor was characterized by XRD, FE-SEM, EDS, FT-IR and differential pulse voltammetry. The oxidation signals of adenine and guanine were in linear range when the device was subjected to various concentrations of GEM, from 1.5 to -93 μM, where a low detection limit 12.5 nmol L−1, and 48.8 nmol L−1 were recorded by guanine and adenine respectively. The developed biosensor did perform very well when employed for the actual samples; the stability was also approved which was acceptable for a reasonable time." @default.
• W2973154258 created "2019-09-19" @default.
• W2973154258 creator A5013810398 @default.
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• W2973154258 creator A5060847151 @default.
• W2973154258 creator A5085815453 @default.
• W2973154258 date "2019-12-01" @default.
• W2973154258 modified "2023-09-27" @default.
• W2973154258 title "Electrochemical molecularly bioimprinted siloxane biosensor on the basis of core/shell silver nanoparticles/EGFR exon 21 L858R point mutant gene/siloxane film for ultra-sensing of Gemcitabine as a lung cancer chemotherapy medication" @default.
• W2973154258 cites W1526666312 @default.
• W2973154258 cites W1804698935 @default.
• W2973154258 cites W1936647867 @default.
• W2973154258 cites W1966912450 @default.
• W2973154258 cites W1968449310 @default.
• W2973154258 cites W1973561324 @default.
• W2973154258 cites W1979212284 @default.
• W2973154258 cites W1983396320 @default.
• W2973154258 cites W1985530935 @default.
• W2973154258 cites W1986292001 @default.
• W2973154258 cites W1987112993 @default.
• W2973154258 cites W1989370595 @default.
• W2973154258 cites W1994455753 @default.
• W2973154258 cites W1995992576 @default.
• W2973154258 cites W2002246861 @default.
• W2973154258 cites W2002728631 @default.
• W2973154258 cites W2005326791 @default.
• W2973154258 cites W2008250662 @default.
• W2973154258 cites W2008908065 @default.
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• W2973154258 cites W2023022678 @default.
• W2973154258 cites W2024700582 @default.
• W2973154258 cites W2025247466 @default.
• W2973154258 cites W2026414990 @default.
• W2973154258 cites W2026799041 @default.
• W2973154258 cites W2027310997 @default.
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• W2973154258 cites W2032994792 @default.
• W2973154258 cites W2034263500 @default.
• W2973154258 cites W2035258397 @default.
• W2973154258 cites W2037466436 @default.
• W2973154258 cites W2045149855 @default.
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• W2973154258 cites W2061102136 @default.
• W2973154258 cites W2066418771 @default.
• W2973154258 cites W2071585440 @default.
• W2973154258 cites W2074396493 @default.
• W2973154258 cites W2082326641 @default.
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• W2973154258 doi "https://doi.org/10.1016/j.bios.2019.111611" @default.
• W2973154258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31550632" @default.
• W2973154258 hasPublicationYear "2019" @default.
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