Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980456946> ?p ?o ?g. }
- W2980456946 abstract "Abstract Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder, which causes dysfunction/loss of lower motor neurons and muscle weakness as well as atrophy. While SMA is primarily considered as a motor neuron disease, recent data suggests that survival motor neuron (SMN) deficiency in muscle causes intrinsic defects. We systematically profiled secreted proteins from control and SMN deficient muscle cells with two combined metabolic labeling methods and mass spectrometry. From the screening, we found lower levels of C1q/TNF-related protein 3 (CTRP3) in the SMA muscle secretome and confirmed that CTRP3 levels are indeed reduced in muscle tissues and serum of an SMA mouse model. We identified that CTRP3 regulates neuronal protein synthesis including SMN via mTOR pathway. Furthermore, CTRP3 enhances axonal outgrowth and protein synthesis rate, which are well-known impaired processes in SMA motor neurons. Our data revealed a new molecular mechanism by which muscles regulate the physiology of motor neurons via secreted molecules. Dysregulation of this mechanism contributes to the pathophysiology of SMA." @default.
- W2980456946 created "2019-10-25" @default.
- W2980456946 creator A5004598818 @default.
- W2980456946 creator A5007640637 @default.
- W2980456946 creator A5013126308 @default.
- W2980456946 creator A5014099039 @default.
- W2980456946 creator A5014361019 @default.
- W2980456946 creator A5020867814 @default.
- W2980456946 creator A5025842975 @default.
- W2980456946 creator A5040597643 @default.
- W2980456946 creator A5051623556 @default.
- W2980456946 creator A5053874086 @default.
- W2980456946 creator A5070772777 @default.
- W2980456946 date "2019-10-15" @default.
- W2980456946 modified "2023-10-18" @default.
- W2980456946 title "Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy" @default.
- W2980456946 cites W1554872850 @default.
- W2980456946 cites W1568977955 @default.
- W2980456946 cites W1590583659 @default.
- W2980456946 cites W1860265173 @default.
- W2980456946 cites W1904651018 @default.
- W2980456946 cites W1971315869 @default.
- W2980456946 cites W1973368869 @default.
- W2980456946 cites W1980477780 @default.
- W2980456946 cites W1987687980 @default.
- W2980456946 cites W1988037421 @default.
- W2980456946 cites W1988447677 @default.
- W2980456946 cites W1994860823 @default.
- W2980456946 cites W1995294811 @default.
- W2980456946 cites W2003236418 @default.
- W2980456946 cites W2013174632 @default.
- W2980456946 cites W2020999287 @default.
- W2980456946 cites W2025327530 @default.
- W2980456946 cites W2029262926 @default.
- W2980456946 cites W2029906820 @default.
- W2980456946 cites W2031704362 @default.
- W2980456946 cites W2032756767 @default.
- W2980456946 cites W2034605152 @default.
- W2980456946 cites W2047268435 @default.
- W2980456946 cites W2054380003 @default.
- W2980456946 cites W2054584654 @default.
- W2980456946 cites W2056116259 @default.
- W2980456946 cites W2070893666 @default.
- W2980456946 cites W2071346782 @default.
- W2980456946 cites W2073074861 @default.
- W2980456946 cites W2074197666 @default.
- W2980456946 cites W2076828747 @default.
- W2980456946 cites W2079838847 @default.
- W2980456946 cites W2080267978 @default.
- W2980456946 cites W2090705888 @default.
- W2980456946 cites W2094108169 @default.
- W2980456946 cites W2096974177 @default.
- W2980456946 cites W2099118635 @default.
- W2980456946 cites W2102450141 @default.
- W2980456946 cites W2104483488 @default.
- W2980456946 cites W2104506892 @default.
- W2980456946 cites W2110551795 @default.
- W2980456946 cites W2111786954 @default.
- W2980456946 cites W2112430789 @default.
- W2980456946 cites W2124054304 @default.
- W2980456946 cites W2140946052 @default.
- W2980456946 cites W2141701416 @default.
- W2980456946 cites W2147205113 @default.
- W2980456946 cites W2153719074 @default.
- W2980456946 cites W2160739594 @default.
- W2980456946 cites W2163306592 @default.
- W2980456946 cites W2170776626 @default.
- W2980456946 cites W2181472284 @default.
- W2980456946 cites W2201916408 @default.
- W2980456946 cites W2280443309 @default.
- W2980456946 cites W2346267320 @default.
- W2980456946 cites W2463195069 @default.
- W2980456946 cites W2473412742 @default.
- W2980456946 cites W2477368596 @default.
- W2980456946 cites W2504137115 @default.
- W2980456946 cites W2530004925 @default.
- W2980456946 cites W2530437405 @default.
- W2980456946 cites W2537482545 @default.
- W2980456946 cites W2582137641 @default.
- W2980456946 cites W2593894711 @default.
- W2980456946 cites W2606220143 @default.
- W2980456946 cites W2733659072 @default.
- W2980456946 cites W2789894805 @default.
- W2980456946 cites W2801257573 @default.
- W2980456946 cites W2804587613 @default.
- W2980456946 cites W2805012765 @default.
- W2980456946 cites W2810767781 @default.
- W2980456946 cites W2887324870 @default.
- W2980456946 cites W2895793011 @default.
- W2980456946 cites W2896495131 @default.
- W2980456946 cites W2897256944 @default.
- W2980456946 cites W2899991876 @default.
- W2980456946 cites W2900616357 @default.
- W2980456946 cites W2911277088 @default.
- W2980456946 cites W2941385873 @default.
- W2980456946 cites W2943039452 @default.
- W2980456946 cites W2952994284 @default.
- W2980456946 doi "https://doi.org/10.1186/s40478-019-0806-3" @default.
- W2980456946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794869" @default.
- W2980456946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31615574" @default.