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- W2985074328 endingPage "e1008454" @default.
- W2985074328 startingPage "e1008454" @default.
- W2985074328 abstract "α-catenin is a key protein of adherens junctions (AJs) with mechanosensory properties. It also acts as a tumor suppressor that limits tissue growth. Here we analyzed the function of Drosophila α-Catenin (α-Cat) in growth regulation of the wing epithelium. We found that different α-Cat levels led to a differential activation of Hippo/Yorkie or JNK signaling causing tissue overgrowth or degeneration, respectively. α-Cat can modulate Yorkie-dependent tissue growth through recruitment of Ajuba, a negative regulator of Hippo signaling to AJs but also through a mechanism independent of Ajuba recruitment to AJs. Both mechanosensory regions of α-Cat, the M region and the actin-binding domain (ABD), contribute to growth regulation. Whereas M is dispensable for α-Cat function in the wing, individual M domains (M1, M2, M3) have opposing effects on growth regulation. In particular, M1 limits Ajuba recruitment. Loss of M1 causes Ajuba hyper-recruitment to AJs, promoting tissue-tension independent overgrowth. Although M1 binds Vinculin, Vinculin is not responsible for this effect. Moreover, disruption of mechanosensing of the α-Cat ABD affects tissue growth, with enhanced actin interactions stabilizing junctions and leading to tissue overgrowth. Together, our findings indicate that α-Cat acts through multiple mechanisms to control tissue growth, including regulation of AJ stability, mechanosensitive Ajuba recruitment, and dynamic direct F-actin interactions." @default.
- W2985074328 created "2019-11-22" @default.
- W2985074328 creator A5016301586 @default.
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- W2985074328 date "2019-11-07" @default.
- W2985074328 modified "2023-10-18" @default.
- W2985074328 title "Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth" @default.
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- W2985074328 doi "https://doi.org/10.1371/journal.pgen.1008454" @default.
- W2985074328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6863567" @default.
- W2985074328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31697683" @default.
- W2985074328 hasPublicationYear "2019" @default.
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