FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2994037086> ?p ?o ?g. }

• W2994037086 endingPage "843" @default.
• W2994037086 startingPage "833" @default.
• W2994037086 abstract "Drug-induced liver injury is not readily detectable using conventional animal studies during pre-clinical drug development. To address this problem, other researchers have proposed the use of co-administration of lipopolysaccharide (LPS), an endotoxin produced by gram-negative bacteria, and a drug. Using this approach, liver injury that is otherwise not detected following drug administration alone can be successfully identified. Previous studies have demonstrated that such injury is suppressed by heparin; therefore, the mechanism may involve coagulation-dependent ischemia. However, it has not been established how LPS-induced ischemia might sensitize hepatocytes to a potentially hepatotoxic drug. In the present study, we aimed to determine the effect of LPS-induced ischemia on liver mitochondrial function and downstream toxicologic responses. Consistent with previous findings, plasma alanine transaminase (ALT) activity was higher in rats co-administered with LPS (1 mg/kg) and diclofenac (100 mg/kg), but reduced by heparin. Liver mRNA expression of Hmox1, encoding heme oxygenase-1, an oxidative stress indicator, was three times higher at 2 hr after LPS administration. Furthermore, respiratory activity via mitochondrial complex II, lipid peroxidation in mitochondria, and the susceptibility to mitochondrial permeability transition pore opening in response to diclofenac administration were significantly increased by LPS administration. The increase in plasma ALT activity and the sensitization to mitochondrial permeability transition pore opening were reduced by the co-administration of heparin. In conclusion, LPS-induced transient ischemia disrupts respiratory chain complex activities, enhances reactive oxygen species production, especially in mitochondria, and sensitizes mitochondria to permeability transition pore opening when testing a potentially hepatotoxic drug in vivo." @default.
• W2994037086 created "2019-12-13" @default.
• W2994037086 creator A5001088254 @default.
• W2994037086 creator A5002181472 @default.
• W2994037086 creator A5023107954 @default.
• W2994037086 creator A5028946089 @default.
• W2994037086 creator A5043482117 @default.
• W2994037086 creator A5046112429 @default.
• W2994037086 date "2019-01-01" @default.
• W2994037086 modified "2023-10-03" @default.
• W2994037086 title "Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model" @default.
• W2994037086 cites W1655860314 @default.
• W2994037086 cites W1775749144 @default.
• W2994037086 cites W1997491414 @default.
• W2994037086 cites W1998101020 @default.
• W2994037086 cites W2001668931 @default.
• W2994037086 cites W2003181581 @default.
• W2994037086 cites W2003425030 @default.
• W2994037086 cites W2004364523 @default.
• W2994037086 cites W2008539746 @default.
• W2994037086 cites W2018336038 @default.
• W2994037086 cites W2036523827 @default.
• W2994037086 cites W2037187444 @default.
• W2994037086 cites W2046965971 @default.
• W2994037086 cites W2049151398 @default.
• W2994037086 cites W2059349976 @default.
• W2994037086 cites W2060261844 @default.
• W2994037086 cites W2063284227 @default.
• W2994037086 cites W2069545578 @default.
• W2994037086 cites W2070952520 @default.
• W2994037086 cites W2081048081 @default.
• W2994037086 cites W2087852901 @default.
• W2994037086 cites W2088629175 @default.
• W2994037086 cites W2094395963 @default.
• W2994037086 cites W2097080185 @default.
• W2994037086 cites W2112889482 @default.
• W2994037086 cites W2116993390 @default.
• W2994037086 cites W2123759002 @default.
• W2994037086 cites W2124094752 @default.
• W2994037086 cites W2124723131 @default.
• W2994037086 cites W2126856735 @default.
• W2994037086 cites W2130508542 @default.
• W2994037086 cites W2133570600 @default.
• W2994037086 cites W2137132053 @default.
• W2994037086 cites W2145047965 @default.
• W2994037086 cites W2158447440 @default.
• W2994037086 cites W2159239906 @default.
• W2994037086 cites W2263023695 @default.
• W2994037086 cites W2278644499 @default.
• W2994037086 cites W2341142213 @default.
• W2994037086 cites W2593604375 @default.
• W2994037086 cites W2598381146 @default.
• W2994037086 cites W2796104433 @default.
• W2994037086 cites W2802240241 @default.
• W2994037086 cites W2811397251 @default.
• W2994037086 cites W2892919624 @default.
• W2994037086 cites W2902743663 @default.
• W2994037086 cites W2903758724 @default.
• W2994037086 cites W2950789682 @default.
• W2994037086 cites W4240753902 @default.
• W2994037086 doi "https://doi.org/10.2131/jts.44.833" @default.
• W2994037086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31813902" @default.
• W2994037086 hasPublicationYear "2019" @default.
• W2994037086 type Work @default.
• W2994037086 sameAs 2994037086 @default.
• W2994037086 citedByCount "4" @default.
• W2994037086 countsByYear W29940370862020 @default.
• W2994037086 countsByYear W29940370862021 @default.
• W2994037086 countsByYear W29940370862023 @default.
• W2994037086 crossrefType "journal-article" @default.
• W2994037086 hasAuthorship W2994037086A5001088254 @default.
• W2994037086 hasAuthorship W2994037086A5002181472 @default.
• W2994037086 hasAuthorship W2994037086A5023107954 @default.
• W2994037086 hasAuthorship W2994037086A5028946089 @default.
• W2994037086 hasAuthorship W2994037086A5043482117 @default.
• W2994037086 hasAuthorship W2994037086A5046112429 @default.
• W2994037086 hasBestOaLocation W29940370861 @default.
• W2994037086 hasConcept C126322002 @default.
• W2994037086 hasConcept C13591479 @default.
• W2994037086 hasConcept C185592680 @default.
• W2994037086 hasConcept C190283241 @default.
• W2994037086 hasConcept C203014093 @default.
• W2994037086 hasConcept C2776151105 @default.
• W2994037086 hasConcept C2776637226 @default.
• W2994037086 hasConcept C2778606649 @default.
• W2994037086 hasConcept C2778754761 @default.
• W2994037086 hasConcept C2780829032 @default.
• W2994037086 hasConcept C28859421 @default.
• W2994037086 hasConcept C31573885 @default.
• W2994037086 hasConcept C541997718 @default.
• W2994037086 hasConcept C55493867 @default.
• W2994037086 hasConcept C71924100 @default.
• W2994037086 hasConcept C98274493 @default.
• W2994037086 hasConceptScore W2994037086C126322002 @default.
• W2994037086 hasConceptScore W2994037086C13591479 @default.
• W2994037086 hasConceptScore W2994037086C185592680 @default.
• W2994037086 hasConceptScore W2994037086C190283241 @default.
• W2994037086 hasConceptScore W2994037086C203014093 @default.

• next