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• W2996317077 abstract "Background Fibroblasts executing directional migration position their centrosome, and their Golgi apparatus, in front of the nucleus towards the cell leading edge. Centrosome positioning relative to the nucleus has been associated to mechanical forces exerted on the centrosome by the microtubule‐dependent molecular motor cytoplasmic dynein 1, and to nuclear movements such as rearward displacement and rotation events. Dynein has been proposed to regulate the position of the centrosome by exerting pulling forces on microtubules from the cell leading edge, where the motor is enriched during migration. However, the mechanism explaining how dynein acts at the front of the cells has not been elucidated. Results We present here results showing that the protein Focal Adhesion Kinase (FAK) interacts with dynein and regulates the enrichment of the dynein/dynactin complex at focal adhesions at the cell the leading edge of migrating fibroblasts. This suggests that focal adhesions provide anchoring sites for dynein during the polarisation process. In support of this, we present evidence indicating that the interaction between FAK and dynein, which is regulated by the phosphorylation of FAK on its Ser732 residue, is required for proper centrosome positioning. Our results further show that the polarisation of the centrosome can occur independently of nuclear movements. Although FAK regulates both nuclear and centrosome motilities, downregulating the interaction between FAK and dynein affects only the nuclear independent polarisation of the centrosome. Conclusions Our work highlights the role of FAK as a key player in the regulation of several aspects of cell polarity. We thus propose a model in which the transient localisation of dynein with focal adhesions provides a tuneable mechanism to bias dynein traction forces on microtubules allowing proper centrosome positioning in front of the nucleus. Significance We unravel here a new role for the cancer therapeutic target FAK in the regulation of cell morphogenesis." @default.
• W2996317077 created "2019-12-26" @default.
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• W2996317077 date "2020-01-09" @default.
• W2996317077 modified "2023-10-18" @default.
• W2996317077 title "FAK regulates dynein localisation and cell polarity in migrating mouse fibroblasts" @default.
• W2996317077 cites W1561407320 @default.
• W2996317077 cites W1964006565 @default.
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• W2996317077 cites W1970771850 @default.
• W2996317077 cites W1984374880 @default.
• W2996317077 cites W1987704865 @default.
• W2996317077 cites W1990905826 @default.
• W2996317077 cites W1992125801 @default.
• W2996317077 cites W1992869573 @default.
• W2996317077 cites W2002267001 @default.
• W2996317077 cites W2005748892 @default.
• W2996317077 cites W2007744474 @default.
• W2996317077 cites W2012678565 @default.
• W2996317077 cites W2014703919 @default.
• W2996317077 cites W2015961658 @default.
• W2996317077 cites W2017947288 @default.
• W2996317077 cites W2023616689 @default.
• W2996317077 cites W2026632078 @default.
• W2996317077 cites W2028691987 @default.
• W2996317077 cites W2029481305 @default.
• W2996317077 cites W2030582971 @default.
• W2996317077 cites W2031920140 @default.
• W2996317077 cites W2036024620 @default.
• W2996317077 cites W2039354378 @default.
• W2996317077 cites W2040258779 @default.
• W2996317077 cites W2044687652 @default.
• W2996317077 cites W2049046584 @default.
• W2996317077 cites W2052473333 @default.
• W2996317077 cites W2054923387 @default.
• W2996317077 cites W2055236272 @default.
• W2996317077 cites W2056591712 @default.
• W2996317077 cites W2056986410 @default.
• W2996317077 cites W2057989196 @default.
• W2996317077 cites W2062556331 @default.
• W2996317077 cites W2071847651 @default.
• W2996317077 cites W2072339613 @default.
• W2996317077 cites W2083601800 @default.
• W2996317077 cites W2083962935 @default.
• W2996317077 cites W2089693405 @default.
• W2996317077 cites W2092619797 @default.
• W2996317077 cites W2102283558 @default.
• W2996317077 cites W2102331414 @default.
• W2996317077 cites W2111186211 @default.
• W2996317077 cites W2111428426 @default.
• W2996317077 cites W2112273204 @default.
• W2996317077 cites W2115779247 @default.
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• W2996317077 cites W2120636641 @default.
• W2996317077 cites W2123299216 @default.
• W2996317077 cites W2129251085 @default.
• W2996317077 cites W2132804958 @default.
• W2996317077 cites W2133059825 @default.
• W2996317077 cites W2138879453 @default.
• W2996317077 cites W2141391862 @default.
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• W2996317077 cites W2157920463 @default.
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• W2996317077 cites W2167463357 @default.
• W2996317077 cites W2168733588 @default.
• W2996317077 cites W2888558935 @default.
• W2996317077 cites W4321428292 @default.
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• W2996317077 doi "https://doi.org/10.1111/boc.201900041" @default.
• W2996317077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31859373" @default.
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