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- W2999702964 abstract "This chapter presents the current advancements toward medical data harmonization to overcome the structural heterogeneities that are present in the clinical data. The benefits of data harmonization are first described along with the requirements and the underlying threats toward the realization and success of data harmonization, as well as its difference from data standardization. Novel technical approaches and tools are presented to enable data harmonization including lexical and semantic matching, item response theory, and statistical approaches, as well. Emphasis is given on the importance of the reference model and the construction of ontologies which serve as gold standards for data harmonization. Global initiatives in the clinical domain are finally discussed toward the establishment of a generalized harmonization strategy." @default.
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- W2999702964 date "2020-01-01" @default.
- W2999702964 modified "2023-09-25" @default.
- W2999702964 title "Medical data harmonization" @default.
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- W2999702964 doi "https://doi.org/10.1016/b978-0-12-816507-2.00005-0" @default.
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