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• W3000058993 abstract "Oxidation of a highly conserved cysteine (Cys) residue located in the kinase activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue is conserved in the fission yeast Schizosaccharomyces pombe MAPKK Wis1, which belongs to the H 2 O 2 -responsive MAPK Sty1 pathway. Here, we show that H 2 O 2 reversibly inactivates Wis1 through this residue (C458) in vitro ." @default.
• W3000058993 created "2020-01-23" @default.
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• W3000058993 date "2020-03-16" @default.
• W3000058993 modified "2023-09-27" @default.
• W3000058993 title "A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H ₂ O ₂ and Is the Target of a Small Molecule" @default.
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• W3000058993 doi "https://doi.org/10.1128/mcb.00346-19" @default.
• W3000058993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7076255" @default.
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