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• W3024750515 abstract "Abstract The role of prostaglandin E 2 (PGE 2 ) in the successful resumption of oocyte meiosis and cumulus expansion has been well-documented. However, there remains very little information available on the influence of PGE 2 on other processes that occur during oocyte maturation. In this study, we supplemented a maturation medium with PGE 2 and monitored oocyte quality markers, glucose metabolism, mitochondrial status, oxidative stress, and apoptosis in the cumulus-oocyte complexes (COCs), using a well-established in vitro model of embryo production in cattle. We found that this increased availability of PGE 2 during maturation led to an increase in the expression of genes associated with oocyte competence and improved the quality of blastocysts produced. Prostaglandin E 2 also appeared to stimulate glucose uptake and lactate production in the COCs, both influencing the expression of enzymes involved in glycolysis and the hexosamine biosynthetic pathway. We found that PGE 2 reduced intracellular reactive oxygen species levels, and simultaneously increased glutathione concentration and stimulated antioxidant gene expression in the oocyte. These results indicate that PGE 2 has an important role in the protection of oocytes against oxidative stress. Mitochondrial membrane potential was also improved in PGE 2 -treated oocytes, and there was a reduction in the occurrence of apoptosis in the COCs. Promotion of an anti-apoptotic balance in transcription of genes involved in apoptosis was present in both oocytes and the cumulus cells. In summary, PGE 2 could represent a novel autocrine/paracrine player in the mechanisms that can facilitate successful oocyte maturation and oocyte survival in the cow." @default.
• W3024750515 created "2020-05-21" @default.
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• W3024750515 date "2020-05-11" @default.
• W3024750515 modified "2023-10-18" @default.
• W3024750515 title "Prostaglandin E2 affects in vitro maturation of bovine oocytes" @default.
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• W3024750515 doi "https://doi.org/10.1186/s12958-020-00598-9" @default.
• W3024750515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7216604" @default.
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