Matches in SemOpenAlex for { <https://semopenalex.org/work/W3025385506> ?p ?o ?g. }
- W3025385506 endingPage "112689" @default.
- W3025385506 startingPage "112689" @default.
- W3025385506 abstract "L-Carnitine (LC) is an endogenous compound synthesized from the essential amino acids lysine and methionine. LC act as an antioxidant and modulates the levels of neurochemicals such as glutamate, GABA, NO etc. implicated in the regulation of anxiety and related behavior. However its exact role in the anxiety is not known. The present study was designed to investigate the anxiolytic like effect of LC in mice. LC (2.5, 5.0 and 10 mg/kg, i.p.) was administered to the mice and the anxiety related behavior was determined using light and dark box (LDB) and elevated plus maze (EPM) tests. The whole brain nitrite level was also determined. The results obtained demonstrated that LC (10 mg/kg, i.p.) exerted anxiolytic like effect in mice, accompanied by the reduction of whole brain nitrite level significantly as compared to control. Further, the influence of NO and GABA modulators pretreatments on the effect of subtherapeutic dose of LC was also determined. The results obtained demonstrated that NO donor/cGMP modulator counteracted while NO inhibitor potentiated the effect confers by the subtherapeutic dose of LC mice. Pretreatment of diazepam (1 mg/kg, i.p.) further potentiated the effect of subtherapeutic dose of LC (5 mg/kg, i.p.) in EPM and LDB tests and further reduced the brain nitrite level significantly as compared to LC (5 mg/kg, i.p.) alone treatment. Thus, LC exerted anxiolytic like effect in mice and NO-sGC-cGMP signaling pathway influences the anxiolytic like effect of LC in mice." @default.
- W3025385506 created "2020-05-21" @default.
- W3025385506 creator A5026846006 @default.
- W3025385506 creator A5037373119 @default.
- W3025385506 date "2020-08-01" @default.
- W3025385506 modified "2023-10-16" @default.
- W3025385506 title "Anxiolytic like effect of L-Carnitine in mice: Evidences for the involvement of NO-sGC-cGMP signaling pathway" @default.
- W3025385506 cites W1559609624 @default.
- W3025385506 cites W1888844103 @default.
- W3025385506 cites W1964160578 @default.
- W3025385506 cites W1966385194 @default.
- W3025385506 cites W1967846734 @default.
- W3025385506 cites W1971005608 @default.
- W3025385506 cites W1973537752 @default.
- W3025385506 cites W1973752193 @default.
- W3025385506 cites W1976740393 @default.
- W3025385506 cites W1977016975 @default.
- W3025385506 cites W1977394169 @default.
- W3025385506 cites W1978252824 @default.
- W3025385506 cites W1984859652 @default.
- W3025385506 cites W1987424542 @default.
- W3025385506 cites W1990802251 @default.
- W3025385506 cites W1991828772 @default.
- W3025385506 cites W1992978945 @default.
- W3025385506 cites W1996792749 @default.
- W3025385506 cites W1996977994 @default.
- W3025385506 cites W1997023449 @default.
- W3025385506 cites W1999335686 @default.
- W3025385506 cites W1999925666 @default.
- W3025385506 cites W2000115839 @default.
- W3025385506 cites W2002312324 @default.
- W3025385506 cites W2004928159 @default.
- W3025385506 cites W2006014108 @default.
- W3025385506 cites W2009011613 @default.
- W3025385506 cites W2011651646 @default.
- W3025385506 cites W2013082402 @default.
- W3025385506 cites W2014629518 @default.
- W3025385506 cites W2019465027 @default.
- W3025385506 cites W2019900535 @default.
- W3025385506 cites W2020184819 @default.
- W3025385506 cites W2021108748 @default.
- W3025385506 cites W2026302426 @default.
- W3025385506 cites W2031383268 @default.
- W3025385506 cites W2034199785 @default.
- W3025385506 cites W2036217770 @default.
- W3025385506 cites W2040135097 @default.
- W3025385506 cites W2041341616 @default.
- W3025385506 cites W2041465976 @default.
- W3025385506 cites W2041561931 @default.
- W3025385506 cites W2051876980 @default.
- W3025385506 cites W2055034967 @default.
- W3025385506 cites W2057137756 @default.
- W3025385506 cites W2058184852 @default.
- W3025385506 cites W2061860574 @default.
- W3025385506 cites W2061994450 @default.
- W3025385506 cites W2062105986 @default.
- W3025385506 cites W2062657498 @default.
- W3025385506 cites W2064278932 @default.
- W3025385506 cites W2068617912 @default.
- W3025385506 cites W2068997428 @default.
- W3025385506 cites W2071058325 @default.
- W3025385506 cites W2071293996 @default.
- W3025385506 cites W2072534902 @default.
- W3025385506 cites W2077419301 @default.
- W3025385506 cites W2077760714 @default.
- W3025385506 cites W2084415293 @default.
- W3025385506 cites W2089187573 @default.
- W3025385506 cites W2090802810 @default.
- W3025385506 cites W2104522961 @default.
- W3025385506 cites W2111516110 @default.
- W3025385506 cites W2114634718 @default.
- W3025385506 cites W2118462346 @default.
- W3025385506 cites W2121298627 @default.
- W3025385506 cites W2123811191 @default.
- W3025385506 cites W2125250128 @default.
- W3025385506 cites W2129736272 @default.
- W3025385506 cites W2137498262 @default.
- W3025385506 cites W2162572715 @default.
- W3025385506 cites W2162611266 @default.
- W3025385506 cites W2166054235 @default.
- W3025385506 cites W2168367599 @default.
- W3025385506 cites W2172262465 @default.
- W3025385506 cites W2250318372 @default.
- W3025385506 cites W2353075771 @default.
- W3025385506 cites W2468879160 @default.
- W3025385506 cites W2527144139 @default.
- W3025385506 cites W2536024417 @default.
- W3025385506 cites W2551818052 @default.
- W3025385506 cites W2791912546 @default.
- W3025385506 cites W2797632989 @default.
- W3025385506 cites W2801086494 @default.
- W3025385506 cites W2883690879 @default.
- W3025385506 cites W2909534556 @default.
- W3025385506 cites W2949875429 @default.
- W3025385506 cites W2995813043 @default.
- W3025385506 cites W3002349834 @default.
- W3025385506 cites W3003927600 @default.
- W3025385506 cites W4231981115 @default.