FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3034476589> ?p ?o ?g. }

• W3034476589 endingPage "330" @default.
• W3034476589 startingPage "317" @default.
• W3034476589 abstract "Innate lymphoid cells (ILCs) rapidly undergo expansion in population size and functional maturation in response to cytokines that signal infection, tissue damage, or changes in physiology. Optimal ILC responses are shaped, in part, by the microbiota but the mechanisms remain unclear. We report that short-chain fatty acids (SCFAs), produced by the commensal microbiota from dietary fibers, support optimal expansion of ILCs, including ILC1, ILC2, and ILC3 in the intestines through their G-protein-coupled receptors (GPCRs). While this function is primarily important for intestinal ILC populations, it can also boost ILC responses in other tissues depending on host condition. ILCs express multiple GPCRs that detect SCFAs. Interestingly, we found that the expression of SCFA receptors, such as Ffar2 and Ffar3, by ILCs is induced by SCFAs. GPCR triggering by SCFAs co-stimulates the activation of phosphoinositide 3-kinase (PI3K), Stat3, Stat5, and mammalian target of rapamycin (mTOR), which is important for ILC proliferation. While Ffar2 signaling promotes ILC2 proliferation, SCFAs can suppress ILC2 proliferation through a non-Ffar2-mediated mechanism. In conclusion, our findings indicate that SCFAs, as the major mediator of healthy microbiota and nutritional status, function to maintain optimal numbers of ILCs in peripheral tissues during infection and inflammatory responses." @default.
• W3034476589 created "2020-06-19" @default.
• W3034476589 creator A5019394624 @default.
• W3034476589 creator A5059573045 @default.
• W3034476589 creator A5084743693 @default.
• W3034476589 creator A5085244356 @default.
• W3034476589 date "2021-03-01" @default.
• W3034476589 modified "2023-10-16" @default.
• W3034476589 title "Dietary fiber metabolites regulate innate lymphoid cell responses" @default.
• W3034476589 cites W101807314 @default.
• W3034476589 cites W1873569416 @default.
• W3034476589 cites W1971621147 @default.
• W3034476589 cites W1981177186 @default.
• W3034476589 cites W1981266729 @default.
• W3034476589 cites W1982229304 @default.
• W3034476589 cites W1994863439 @default.
• W3034476589 cites W1995297089 @default.
• W3034476589 cites W1998440908 @default.
• W3034476589 cites W1999906527 @default.
• W3034476589 cites W2001938165 @default.
• W3034476589 cites W2003342633 @default.
• W3034476589 cites W2039907390 @default.
• W3034476589 cites W2044216294 @default.
• W3034476589 cites W2048093113 @default.
• W3034476589 cites W2053305914 @default.
• W3034476589 cites W2057399882 @default.
• W3034476589 cites W2060185417 @default.
• W3034476589 cites W2061440101 @default.
• W3034476589 cites W2067320696 @default.
• W3034476589 cites W2067401763 @default.
• W3034476589 cites W2068089195 @default.
• W3034476589 cites W2068162195 @default.
• W3034476589 cites W2069677284 @default.
• W3034476589 cites W2091512742 @default.
• W3034476589 cites W2108978157 @default.
• W3034476589 cites W2111731663 @default.
• W3034476589 cites W2118455790 @default.
• W3034476589 cites W2134504455 @default.
• W3034476589 cites W2135232490 @default.
• W3034476589 cites W2140206763 @default.
• W3034476589 cites W2145159460 @default.
• W3034476589 cites W2146890677 @default.
• W3034476589 cites W2155997615 @default.
• W3034476589 cites W2162704444 @default.
• W3034476589 cites W2163878401 @default.
• W3034476589 cites W2171529797 @default.
• W3034476589 cites W2216745061 @default.
• W3034476589 cites W2341340846 @default.
• W3034476589 cites W2401038200 @default.
• W3034476589 cites W2409656339 @default.
• W3034476589 cites W2491805933 @default.
• W3034476589 cites W2510684933 @default.
• W3034476589 cites W2626760843 @default.
• W3034476589 cites W2737809424 @default.
• W3034476589 cites W2746722198 @default.
• W3034476589 cites W2753222026 @default.
• W3034476589 cites W2768407817 @default.
• W3034476589 cites W2773338109 @default.
• W3034476589 cites W2790569372 @default.
• W3034476589 cites W2791139490 @default.
• W3034476589 cites W2803398082 @default.
• W3034476589 cites W2809141554 @default.
• W3034476589 cites W2809494687 @default.
• W3034476589 cites W2809595366 @default.
• W3034476589 cites W2888376450 @default.
• W3034476589 cites W2897668519 @default.
• W3034476589 cites W2914479886 @default.
• W3034476589 cites W2944696275 @default.
• W3034476589 cites W2960714332 @default.
• W3034476589 cites W2968090793 @default.
• W3034476589 cites W2981227588 @default.
• W3034476589 cites W2986068954 @default.
• W3034476589 cites W2997188873 @default.
• W3034476589 cites W3012878208 @default.
• W3034476589 cites W4250467159 @default.
• W3034476589 doi "https://doi.org/10.1038/s41385-020-0312-8" @default.
• W3034476589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7736174" @default.
• W3034476589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32541842" @default.
• W3034476589 hasPublicationYear "2021" @default.
• W3034476589 type Work @default.
• W3034476589 sameAs 3034476589 @default.
• W3034476589 citedByCount "65" @default.
• W3034476589 countsByYear W30344765892020 @default.
• W3034476589 countsByYear W30344765892021 @default.
• W3034476589 countsByYear W30344765892022 @default.
• W3034476589 countsByYear W30344765892023 @default.
• W3034476589 crossrefType "journal-article" @default.
• W3034476589 hasAuthorship W3034476589A5019394624 @default.
• W3034476589 hasAuthorship W3034476589A5059573045 @default.
• W3034476589 hasAuthorship W3034476589A5084743693 @default.
• W3034476589 hasAuthorship W3034476589A5085244356 @default.
• W3034476589 hasBestOaLocation W30344765891 @default.
• W3034476589 hasConcept C135285700 @default.
• W3034476589 hasConcept C136449434 @default.
• W3034476589 hasConcept C14036430 @default.
• W3034476589 hasConcept C143121216 @default.
• W3034476589 hasConcept C170493617 @default.
• W3034476589 hasConcept C203014093 @default.

• next