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- W3034785821 abstract "Coronavirus disease 2019 (COVID-19) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in tremendous morbidity and mortality worldwide. A major underlying cause of COVID-19 mortality is a hyperinflammatory cytokine storm in severe/critically ill patients. Although many clinical trials are testing the efficacy of targeting inflammatory cytokines/chemokines in COVID-19 patients, the critical inflammatory mediator initiating COVID-19 patient death is undefined. Here we suggest that the immunopathological pathway leading to COVID-19 mortality can be divided into three stages with distinct clinical features that can be used to guide therapeutic strategies. Our interpretation of the recently published clinical trials from COVID-19 patients suggests that the clinical efficacy in preventing COVID-19 mortality using IL-1 blockade is subjected to notable caveats, while that for IL-6 blockade is suboptimal. We discuss critical factors in determining appropriate inflammatory cytokine/chemokine targets, timing, and combination of treatments to prevent COVID-19 mortality." @default.
- W3034785821 created "2020-06-19" @default.
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- W3034785821 date "2020-07-17" @default.
- W3034785821 modified "2023-10-18" @default.
- W3034785821 title "Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?" @default.
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- W3034785821 doi "https://doi.org/10.3389/fcell.2020.00677" @default.
- W3034785821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379422" @default.
- W3034785821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32766256" @default.
- W3034785821 hasPublicationYear "2020" @default.
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