Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037243268> ?p ?o ?g. }
- W3037243268 endingPage "132" @default.
- W3037243268 startingPage "119" @default.
- W3037243268 abstract "Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers-when assembled with nucleic acids into vehicles-can protect the cargo from degradation and clearance in vivo, and facilitate its transport into intracellular compartments. Design options in polymer synthesis yield a comprehensive range of molecules and resulting vehicle formulations. These properties can be manipulated to achieve stronger association with nucleic acid cargo and cells, improved endosomal escape, or sustained delivery depending on the application. Here, we describe current approaches for polymer use and related strategies for gene delivery in preclinical and clinical applications. Polymer vehicles delivering genetic material have already achieved significant therapeutic endpoints in vitro and in animal models. From our perspective, with preclincal assays that better mimic the in vivo environment, improved strategies for target specificity, and scalable techniques for polymer synthesis, the impact of this therapeutic approach will continue to expand." @default.
- W3037243268 created "2020-07-02" @default.
- W3037243268 creator A5035894049 @default.
- W3037243268 creator A5052296033 @default.
- W3037243268 creator A5058146242 @default.
- W3037243268 creator A5058653027 @default.
- W3037243268 date "2020-01-01" @default.
- W3037243268 modified "2023-10-12" @default.
- W3037243268 title "Polymeric vehicles for nucleic acid delivery" @default.
- W3037243268 cites W123802784 @default.
- W3037243268 cites W1489436358 @default.
- W3037243268 cites W1499573758 @default.
- W3037243268 cites W1509371783 @default.
- W3037243268 cites W1520821663 @default.
- W3037243268 cites W1533307088 @default.
- W3037243268 cites W1576238436 @default.
- W3037243268 cites W1818943734 @default.
- W3037243268 cites W1843302206 @default.
- W3037243268 cites W1851345801 @default.
- W3037243268 cites W1876579582 @default.
- W3037243268 cites W1888572540 @default.
- W3037243268 cites W1901682227 @default.
- W3037243268 cites W1966090623 @default.
- W3037243268 cites W1966962897 @default.
- W3037243268 cites W1967973226 @default.
- W3037243268 cites W1967985930 @default.
- W3037243268 cites W1968279337 @default.
- W3037243268 cites W1968580733 @default.
- W3037243268 cites W1969018013 @default.
- W3037243268 cites W1970965989 @default.
- W3037243268 cites W1972154409 @default.
- W3037243268 cites W1972499566 @default.
- W3037243268 cites W1973050196 @default.
- W3037243268 cites W1975081121 @default.
- W3037243268 cites W1976175169 @default.
- W3037243268 cites W1978460527 @default.
- W3037243268 cites W1978486312 @default.
- W3037243268 cites W1980414709 @default.
- W3037243268 cites W1980562853 @default.
- W3037243268 cites W1983420173 @default.
- W3037243268 cites W1983907583 @default.
- W3037243268 cites W1984122808 @default.
- W3037243268 cites W1985523341 @default.
- W3037243268 cites W1986167007 @default.
- W3037243268 cites W1989564585 @default.
- W3037243268 cites W1989636269 @default.
- W3037243268 cites W1990796256 @default.
- W3037243268 cites W1993507577 @default.
- W3037243268 cites W1993844364 @default.
- W3037243268 cites W1994354502 @default.
- W3037243268 cites W1994846102 @default.
- W3037243268 cites W1995024825 @default.
- W3037243268 cites W1995272148 @default.
- W3037243268 cites W1995956587 @default.
- W3037243268 cites W1995997091 @default.
- W3037243268 cites W1998891630 @default.
- W3037243268 cites W2000136129 @default.
- W3037243268 cites W2000653343 @default.
- W3037243268 cites W2001305340 @default.
- W3037243268 cites W2001825884 @default.
- W3037243268 cites W2002007707 @default.
- W3037243268 cites W2002015794 @default.
- W3037243268 cites W2002151233 @default.
- W3037243268 cites W2003414091 @default.
- W3037243268 cites W2003908748 @default.
- W3037243268 cites W2006604904 @default.
- W3037243268 cites W2008162040 @default.
- W3037243268 cites W2008198508 @default.
- W3037243268 cites W2008538686 @default.
- W3037243268 cites W2014509855 @default.
- W3037243268 cites W2015080610 @default.
- W3037243268 cites W2017111116 @default.
- W3037243268 cites W2017720816 @default.
- W3037243268 cites W2019274418 @default.
- W3037243268 cites W2023104469 @default.
- W3037243268 cites W2027022352 @default.
- W3037243268 cites W2029655522 @default.
- W3037243268 cites W2029903184 @default.
- W3037243268 cites W2030932194 @default.
- W3037243268 cites W2032521697 @default.
- W3037243268 cites W2033244141 @default.
- W3037243268 cites W2035126853 @default.
- W3037243268 cites W2037684467 @default.
- W3037243268 cites W2038283486 @default.
- W3037243268 cites W2038665602 @default.
- W3037243268 cites W2039551908 @default.
- W3037243268 cites W2043069157 @default.
- W3037243268 cites W2044524539 @default.
- W3037243268 cites W2045720003 @default.
- W3037243268 cites W2046606679 @default.
- W3037243268 cites W2046975038 @default.
- W3037243268 cites W2048577516 @default.
- W3037243268 cites W2048983189 @default.
- W3037243268 cites W2049358561 @default.
- W3037243268 cites W2050221254 @default.
- W3037243268 cites W2051663914 @default.
- W3037243268 cites W2055092476 @default.
- W3037243268 cites W2055353965 @default.