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• W3039737580 abstract "We define a system in which the major symbionts that are important to host biology and to the production of secondary metabolites can be cultivated. We show that symbiotic bacteria that are critical to host nutrition and lifestyle also have an immense capacity to produce a multitude of diverse and likely novel bioactive secondary metabolites that could lead to the discovery of drugs and that these pathways are found within shipworm gills. We propose that, by shaping associated microbial communities within the host, the compounds support the ability of shipworms to degrade wood in marine environments. Because these symbionts can be cultivated and genetically manipulated, they provide a powerful model for understanding how secondary metabolism impacts microbial symbiosis." @default.
• W3039737580 created "2020-07-10" @default.
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• W3039737580 date "2020-06-30" @default.
• W3039737580 modified "2023-10-12" @default.
• W3039737580 title "Secondary Metabolism in the Gill Microbiota of Shipworms (Teredinidae) as Revealed by Comparison of Metagenomes and Nearly Complete Symbiont Genomes" @default.
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• W3039737580 doi "https://doi.org/10.1128/msystems.00261-20" @default.
• W3039737580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7329324" @default.
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