FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042493313> ?p ?o ?g. }

• W3042493313 endingPage "3108" @default.
• W3042493313 startingPage "3099" @default.
• W3042493313 abstract "Abstract Background Antimicrobial resistance (AMR) is a rising health threat with 10 million annual casualties estimated by 2050. Appropriate treatment of infectious diseases with the right antibiotics reduces the spread of antibiotic resistance. Today, clinical practice relies on molecular and PCR techniques for pathogen identification and culture-based antibiotic susceptibility testing (AST). Recently, WGS has started to transform clinical microbiology, enabling prediction of resistance phenotypes from genotypes and allowing for more informed treatment decisions. WGS-based AST (WGS-AST) depends on the detection of AMR markers in sequenced isolates and therefore requires AMR reference databases. The completeness and quality of these databases are material to increase WGS-AST performance. Methods We present a systematic evaluation of the performance of publicly available AMR marker databases for resistance prediction on clinical isolates. We used the public databases CARD and ResFinder with a final dataset of 2587 isolates across five clinically relevant pathogens from PATRIC and NDARO, public repositories of antibiotic-resistant bacterial isolates. Results CARD and ResFinder WGS-AST performance had an overall balanced accuracy of 0.52 (±0.12) and 0.66 (±0.18), respectively. Major error rates were higher in CARD (42.68%) than ResFinder (25.06%). However, CARD showed almost no very major errors (1.17%) compared with ResFinder (4.42%). Conclusions We show that AMR databases need further expansion, improved marker annotations per antibiotic rather than per antibiotic class and validated multivariate marker panels to achieve clinical utility, e.g. in order to meet performance requirements such as provided by the FDA for clinical microbiology diagnostic testing." @default.
• W3042493313 created "2020-07-23" @default.
• W3042493313 creator A5019649517 @default.
• W3042493313 creator A5063969808 @default.
• W3042493313 creator A5083893665 @default.
• W3042493313 creator A5085983122 @default.
• W3042493313 creator A5087750652 @default.
• W3042493313 date "2020-07-13" @default.
• W3042493313 modified "2023-10-17" @default.
• W3042493313 title "Large-scale assessment of antimicrobial resistance marker databases for genetic phenotype prediction: a systematic review" @default.
• W3042493313 cites W1970975622 @default.
• W3042493313 cites W1988621565 @default.
• W3042493313 cites W1990535513 @default.
• W3042493313 cites W2032866129 @default.
• W3042493313 cites W2045604845 @default.
• W3042493313 cites W2065191246 @default.
• W3042493313 cites W2073518110 @default.
• W3042493313 cites W2086223988 @default.
• W3042493313 cites W2090563089 @default.
• W3042493313 cites W2099837668 @default.
• W3042493313 cites W2109684694 @default.
• W3042493313 cites W2118688136 @default.
• W3042493313 cites W2128908920 @default.
• W3042493313 cites W2133740160 @default.
• W3042493313 cites W2134001789 @default.
• W3042493313 cites W2134852597 @default.
• W3042493313 cites W2137413050 @default.
• W3042493313 cites W2141041418 @default.
• W3042493313 cites W2149379022 @default.
• W3042493313 cites W2151496242 @default.
• W3042493313 cites W2160122845 @default.
• W3042493313 cites W2203222511 @default.
• W3042493313 cites W2316777574 @default.
• W3042493313 cites W2460324897 @default.
• W3042493313 cites W2544493586 @default.
• W3042493313 cites W2559133556 @default.
• W3042493313 cites W2559452838 @default.
• W3042493313 cites W2739323458 @default.
• W3042493313 cites W2741611011 @default.
• W3042493313 cites W2752848087 @default.
• W3042493313 cites W2768611588 @default.
• W3042493313 cites W2790965800 @default.
• W3042493313 cites W2802901438 @default.
• W3042493313 cites W2887711510 @default.
• W3042493313 cites W2891497705 @default.
• W3042493313 cites W2898631065 @default.
• W3042493313 cites W2899068429 @default.
• W3042493313 cites W2903381708 @default.
• W3042493313 cites W2903909400 @default.
• W3042493313 cites W2926592097 @default.
• W3042493313 cites W2943429827 @default.
• W3042493313 cites W2952693803 @default.
• W3042493313 cites W2967125766 @default.
• W3042493313 cites W2971921228 @default.
• W3042493313 doi "https://doi.org/10.1093/jac/dkaa257" @default.
• W3042493313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7566382" @default.
• W3042493313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32658975" @default.
• W3042493313 hasPublicationYear "2020" @default.
• W3042493313 type Work @default.
• W3042493313 sameAs 3042493313 @default.
• W3042493313 citedByCount "54" @default.
• W3042493313 countsByYear W30424933132020 @default.
• W3042493313 countsByYear W30424933132021 @default.
• W3042493313 countsByYear W30424933132022 @default.
• W3042493313 countsByYear W30424933132023 @default.
• W3042493313 crossrefType "journal-article" @default.
• W3042493313 hasAuthorship W3042493313A5019649517 @default.
• W3042493313 hasAuthorship W3042493313A5063969808 @default.
• W3042493313 hasAuthorship W3042493313A5083893665 @default.
• W3042493313 hasAuthorship W3042493313A5085983122 @default.
• W3042493313 hasAuthorship W3042493313A5087750652 @default.
• W3042493313 hasBestOaLocation W30424933131 @default.
• W3042493313 hasConcept C2992965680 @default.
• W3042493313 hasConcept C41008148 @default.
• W3042493313 hasConcept C501593827 @default.
• W3042493313 hasConcept C71924100 @default.
• W3042493313 hasConcept C77088390 @default.
• W3042493313 hasConcept C86803240 @default.
• W3042493313 hasConcept C89423630 @default.
• W3042493313 hasConcept C94665300 @default.
• W3042493313 hasConceptScore W3042493313C2992965680 @default.
• W3042493313 hasConceptScore W3042493313C41008148 @default.
• W3042493313 hasConceptScore W3042493313C501593827 @default.
• W3042493313 hasConceptScore W3042493313C71924100 @default.
• W3042493313 hasConceptScore W3042493313C77088390 @default.
• W3042493313 hasConceptScore W3042493313C86803240 @default.
• W3042493313 hasConceptScore W3042493313C89423630 @default.
• W3042493313 hasConceptScore W3042493313C94665300 @default.
• W3042493313 hasIssue "11" @default.
• W3042493313 hasLocation W30424933131 @default.
• W3042493313 hasLocation W30424933132 @default.
• W3042493313 hasOpenAccess W3042493313 @default.
• W3042493313 hasPrimaryLocation W30424933131 @default.
• W3042493313 hasRelatedWork W2029063045 @default.
• W3042493313 hasRelatedWork W2076505260 @default.
• W3042493313 hasRelatedWork W2507683919 @default.
• W3042493313 hasRelatedWork W2955020749 @default.
• W3042493313 hasRelatedWork W2972127693 @default.

• next