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- W3044218786 abstract "The establishment of silent chromatin, a heterochromatin-like structure at HML and HMR in Saccharomyces cerevisiae , depends on progression through S phase of the cell cycle, but the molecular nature of this requirement has remained elusive despite intensive study. Using high-resolution chromatin immunoprecipitation and single-molecule RNA analysis, we found that silencing establishment proceeded via gradual repression of transcription in individual cells over several cell cycles, and that the cell-cycle-regulated step was downstream of Sir protein recruitment. In contrast to prior results, HML and HMR had identical cell-cycle requirements for silencing establishment, with no apparent contribution from a tRNA gene adjacent to HMR . We identified the cause of the S-phase requirement for silencing establishment: removal of transcription-favoring histone modifications deposited by Dot1, Sas2, and Rtt109. These results revealed that silencing establishment was absolutely dependent on the cell-cycle-regulated interplay between euchromatic and heterochromatic histone modifications." @default.
- W3044218786 created "2020-07-29" @default.
- W3044218786 creator A5038166405 @default.
- W3044218786 creator A5065579974 @default.
- W3044218786 date "2020-07-20" @default.
- W3044218786 modified "2023-10-15" @default.
- W3044218786 title "S-phase-independent silencing establishment in Saccharomyces cerevisiae" @default.
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- W3044218786 doi "https://doi.org/10.7554/elife.58910" @default.
- W3044218786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7398696" @default.
- W3044218786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32687055" @default.
- W3044218786 hasPublicationYear "2020" @default.
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