FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3045981304> ?p ?o ?g. }

• W3045981304 endingPage "13" @default.
• W3045981304 startingPage "1" @default.
• W3045981304 abstract "Dementia is an ominous neurological disease. Scientists proposed a link between its occurrence and the presence of Toxoplasma gondii ( T. gondii) . The long-term sequels of anti- Toxoplasma premunition, chiefly dominated by TNF- α , on the neurons and their receptors as the insulin-like growth factor-1 receptor (IGF-1R), which is tangled in cognition and synaptic plasticity, are still not clear. IGF-1R mediates its action via IGF-1, and its depletion is incorporated in the pathogenesis of dementia. The activated TNF- α signaling pathway induces NF- κβ that may induce or inhibit neurogenesis. This study speculates the potential impact of anti- Toxoplasma immune response on the expression of IGF-1R in chronic cerebral toxoplasmosis. The distributive pattern of T. gondii cysts was studied in association with TNF- α serum levels, the in situ expression of NF- κβ , and IGF-1R in mice using the low virulent ME-49 T. gondii strain. There was an elevation of the TNF- α serum level (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi></mml:math>value ≤ 0.004) and significant upsurge in NF- κβ whereas IGF-1R was of low abundance (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi></mml:math>value < 0.05) compared to the controls. TNF- α had a strong positive correlation with the intracerebral expression of NF- κβ (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>r</mml:mi></mml:math>value ≈ 0.943,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi></mml:math>value ≈ 0.005) and a strong negative correlation to IGF-1R (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>r</mml:mi></mml:math>value -0.584 and -0.725 for area% and O.D., respectively). This activated TNF- α /NF- κβ keeps T. gondii under control at the expense of IGF-1R expression, depriving neurons of the effect of IGF-1, the receptor’s ligand. We therefore deduce that T. gondii immunopathological reaction may be a road paver for developing dementia." @default.
• W3045981304 created "2020-08-03" @default.
• W3045981304 creator A5044793512 @default.
• W3045981304 creator A5059167201 @default.
• W3045981304 creator A5067203005 @default.
• W3045981304 creator A5067564455 @default.
• W3045981304 creator A5073496933 @default.
• W3045981304 creator A5077115301 @default.
• W3045981304 creator A5081757363 @default.
• W3045981304 date "2020-07-30" @default.
• W3045981304 modified "2023-10-16" @default.
• W3045981304 title "Can<i>Toxoplasma gondii</i>Pave the Road for Dementia?" @default.
• W3045981304 cites W138775755 @default.
• W3045981304 cites W1496007453 @default.
• W3045981304 cites W1512425047 @default.
• W3045981304 cites W1533168481 @default.
• W3045981304 cites W1534350900 @default.
• W3045981304 cites W1556074890 @default.
• W3045981304 cites W1556183875 @default.
• W3045981304 cites W1585635925 @default.
• W3045981304 cites W1695430850 @default.
• W3045981304 cites W1940522739 @default.
• W3045981304 cites W1954510886 @default.
• W3045981304 cites W1965860042 @default.
• W3045981304 cites W1965965389 @default.
• W3045981304 cites W1970753345 @default.
• W3045981304 cites W1971240021 @default.
• W3045981304 cites W1971715709 @default.
• W3045981304 cites W1972071205 @default.
• W3045981304 cites W1975028446 @default.
• W3045981304 cites W1977707794 @default.
• W3045981304 cites W1978853688 @default.
• W3045981304 cites W1979505121 @default.
• W3045981304 cites W1991495749 @default.
• W3045981304 cites W1993511099 @default.
• W3045981304 cites W1995866519 @default.
• W3045981304 cites W1999768498 @default.
• W3045981304 cites W2000499004 @default.
• W3045981304 cites W2007108789 @default.
• W3045981304 cites W2008403890 @default.
• W3045981304 cites W2011711485 @default.
• W3045981304 cites W2014887370 @default.
• W3045981304 cites W2016195251 @default.
• W3045981304 cites W2016678016 @default.
• W3045981304 cites W2017958484 @default.
• W3045981304 cites W2018842837 @default.
• W3045981304 cites W2023565096 @default.
• W3045981304 cites W2025135714 @default.
• W3045981304 cites W2033403696 @default.
• W3045981304 cites W2037908014 @default.
• W3045981304 cites W2046041725 @default.
• W3045981304 cites W2046597624 @default.
• W3045981304 cites W2050068554 @default.
• W3045981304 cites W2053215305 @default.
• W3045981304 cites W2053889157 @default.
• W3045981304 cites W2057971268 @default.
• W3045981304 cites W2058714321 @default.
• W3045981304 cites W2061313710 @default.
• W3045981304 cites W2075103814 @default.
• W3045981304 cites W2079409189 @default.
• W3045981304 cites W2087641892 @default.
• W3045981304 cites W2098009444 @default.
• W3045981304 cites W2099129157 @default.
• W3045981304 cites W2100849031 @default.
• W3045981304 cites W2101187328 @default.
• W3045981304 cites W2104637120 @default.
• W3045981304 cites W2105896882 @default.
• W3045981304 cites W2110620969 @default.
• W3045981304 cites W2111200149 @default.
• W3045981304 cites W2115452562 @default.
• W3045981304 cites W2116955690 @default.
• W3045981304 cites W2118508881 @default.
• W3045981304 cites W2134406000 @default.
• W3045981304 cites W2137977906 @default.
• W3045981304 cites W2140323371 @default.
• W3045981304 cites W2141599242 @default.
• W3045981304 cites W2143229107 @default.
• W3045981304 cites W2145045466 @default.
• W3045981304 cites W2149917645 @default.
• W3045981304 cites W2151892297 @default.
• W3045981304 cites W2152283755 @default.
• W3045981304 cites W2152469909 @default.
• W3045981304 cites W2156407009 @default.
• W3045981304 cites W2160633906 @default.
• W3045981304 cites W2166279367 @default.
• W3045981304 cites W2198664180 @default.
• W3045981304 cites W2201786905 @default.
• W3045981304 cites W2265856797 @default.
• W3045981304 cites W2292634471 @default.
• W3045981304 cites W2314879238 @default.
• W3045981304 cites W231832547 @default.
• W3045981304 cites W2318634761 @default.
• W3045981304 cites W2329336071 @default.
• W3045981304 cites W2342179942 @default.
• W3045981304 cites W2409761273 @default.
• W3045981304 cites W2500109500 @default.
• W3045981304 cites W2588828083 @default.
• W3045981304 cites W2597906971 @default.

• next