FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047983721> ?p ?o ?g. }

• W3047983721 abstract "Increased oxidative stress is well known to cause testicular dysfunction in aging males, but the detailed relationships between aging, oxidative stress, and testicular function remain to be elucidated. LIM and cysteine-rich domains 1 (LMCD1) regulates fundamentally cellular process by interacting with transcription factors. A recent study has identified Lmcd1 as one of the most upregulated nuclear proteins associated with Sertoli cell (SC) differentiation, raising the possibility that testicular actions of LMCD1 are likely to take place. Herein, we reported that LMCD1 was exclusively expressed in the nuclei of SCs. This expression was regulated by TNF-α signaling produced by apoptotic germ cells (GCs) and was suppressed by oxidative stress in a STAT3-dependent manner. Ablation of endogenous LMCD1 expression caused lipid accumulation and senescence in GC co-incubated SCs. Using a previously validated in vivo siRNA approach, we showed that LMCD1 depletion significantly impaired male fertility by inducing oligozoospermia and asthenospermia. Mechanistically, LMCD1 upregulation was associated with the nuclear enrichment of the nuclear factor of activated T cells 1 (NFAT1), a core component of Ca2+/calmodulin-dependent pathway. LMCD1 facilitated the dephosphorylation and nuclear translocation of NFAT1, which consequently expedited the transactivation of Txlna, a binding partner of the syntaxin family essential for testicular phagocytosis, and thus promoted the removal of apoptotic GCs by phagocytic SCs. Collectively, LMCD1 may operate as a novel pretranscriptional integrator linking SC phagocytosis, lipid homeostasis, and cell senescence." @default.
• W3047983721 created "2020-08-13" @default.
• W3047983721 creator A5000432967 @default.
• W3047983721 creator A5004059954 @default.
• W3047983721 creator A5004118664 @default.
• W3047983721 creator A5010515520 @default.
• W3047983721 creator A5037828767 @default.
• W3047983721 creator A5047855118 @default.
• W3047983721 creator A5091185375 @default.
• W3047983721 date "2020-08-09" @default.
• W3047983721 modified "2023-10-16" @default.
• W3047983721 title "Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway" @default.
• W3047983721 cites W1967697608 @default.
• W3047983721 cites W1968324610 @default.
• W3047983721 cites W1976820828 @default.
• W3047983721 cites W1991688383 @default.
• W3047983721 cites W2018775174 @default.
• W3047983721 cites W2058413014 @default.
• W3047983721 cites W2065433877 @default.
• W3047983721 cites W2071290332 @default.
• W3047983721 cites W2082686635 @default.
• W3047983721 cites W2085364628 @default.
• W3047983721 cites W2091066284 @default.
• W3047983721 cites W2097164822 @default.
• W3047983721 cites W2102395838 @default.
• W3047983721 cites W2115014954 @default.
• W3047983721 cites W2119969366 @default.
• W3047983721 cites W2126808626 @default.
• W3047983721 cites W2130211930 @default.
• W3047983721 cites W2135086572 @default.
• W3047983721 cites W2141816731 @default.
• W3047983721 cites W2149205601 @default.
• W3047983721 cites W2152461652 @default.
• W3047983721 cites W2153816276 @default.
• W3047983721 cites W2156486170 @default.
• W3047983721 cites W2165569789 @default.
• W3047983721 cites W2166637848 @default.
• W3047983721 cites W2184271569 @default.
• W3047983721 cites W2318114413 @default.
• W3047983721 cites W2329185397 @default.
• W3047983721 cites W2417021250 @default.
• W3047983721 cites W2423170580 @default.
• W3047983721 cites W2613880529 @default.
• W3047983721 cites W2737928195 @default.
• W3047983721 cites W2765176323 @default.
• W3047983721 cites W2781976982 @default.
• W3047983721 cites W2784237670 @default.
• W3047983721 cites W2896830728 @default.
• W3047983721 cites W2900743432 @default.
• W3047983721 doi "https://doi.org/10.1111/acel.13217" @default.
• W3047983721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7576262" @default.
• W3047983721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32840323" @default.
• W3047983721 hasPublicationYear "2020" @default.
• W3047983721 type Work @default.
• W3047983721 sameAs 3047983721 @default.
• W3047983721 citedByCount "14" @default.
• W3047983721 countsByYear W30479837212021 @default.
• W3047983721 countsByYear W30479837212022 @default.
• W3047983721 countsByYear W30479837212023 @default.
• W3047983721 crossrefType "journal-article" @default.
• W3047983721 hasAuthorship W3047983721A5000432967 @default.
• W3047983721 hasAuthorship W3047983721A5004059954 @default.
• W3047983721 hasAuthorship W3047983721A5004118664 @default.
• W3047983721 hasAuthorship W3047983721A5010515520 @default.
• W3047983721 hasAuthorship W3047983721A5037828767 @default.
• W3047983721 hasAuthorship W3047983721A5047855118 @default.
• W3047983721 hasAuthorship W3047983721A5091185375 @default.
• W3047983721 hasBestOaLocation W30479837211 @default.
• W3047983721 hasConcept C104317684 @default.
• W3047983721 hasConcept C123765429 @default.
• W3047983721 hasConcept C127561419 @default.
• W3047983721 hasConcept C134018914 @default.
• W3047983721 hasConcept C160448771 @default.
• W3047983721 hasConcept C2776151105 @default.
• W3047983721 hasConcept C2781068068 @default.
• W3047983721 hasConcept C54355233 @default.
• W3047983721 hasConcept C86339819 @default.
• W3047983721 hasConcept C86803240 @default.
• W3047983721 hasConcept C95444343 @default.
• W3047983721 hasConceptScore W3047983721C104317684 @default.
• W3047983721 hasConceptScore W3047983721C123765429 @default.
• W3047983721 hasConceptScore W3047983721C127561419 @default.
• W3047983721 hasConceptScore W3047983721C134018914 @default.
• W3047983721 hasConceptScore W3047983721C160448771 @default.
• W3047983721 hasConceptScore W3047983721C2776151105 @default.
• W3047983721 hasConceptScore W3047983721C2781068068 @default.
• W3047983721 hasConceptScore W3047983721C54355233 @default.
• W3047983721 hasConceptScore W3047983721C86339819 @default.
• W3047983721 hasConceptScore W3047983721C86803240 @default.
• W3047983721 hasConceptScore W3047983721C95444343 @default.
• W3047983721 hasFunder F4320321001 @default.
• W3047983721 hasIssue "10" @default.
• W3047983721 hasLocation W30479837211 @default.
• W3047983721 hasLocation W30479837212 @default.
• W3047983721 hasOpenAccess W3047983721 @default.
• W3047983721 hasPrimaryLocation W30479837211 @default.
• W3047983721 hasRelatedWork W1987845804 @default.
• W3047983721 hasRelatedWork W2020841018 @default.
• W3047983721 hasRelatedWork W2093565969 @default.
• W3047983721 hasRelatedWork W2097164822 @default.

• next