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• W3048391025 abstract "Since both O-GlcNAcylation and autophagy sense intracellular nutrient level, the alteration of those two pathways plays substantial roles in the progression of heart failure. Hence, determining the relationship between O-GlcNAcylation and autophagy is imperative to understand, prevent, and treat heart failure. However, the mechanism on how O-GlcNAcylation regulates autophagy in the heart is poorly investigated. In this study, we demonstrated that O-GlcNAcylation is required for autophagy in cardiomyocytes by utilizing an O-linked β -N-acetylglucosamine transferase (OGT) cardiomyocyte-specific knockout mouse model for the first time. We also identified that OGT might regulate the initiation of autophagy in cardiomyocytes through promoting the activity of ULK1 by O-GlcNAcylation. In conclusion, our findings provide new insights into the molecular mechanisms underlying heart dysfunction and benefit the development of treatments for heart failure." @default.
• W3048391025 created "2020-08-18" @default.
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• W3048391025 date "2020-08-11" @default.
• W3048391025 modified "2023-10-16" @default.
• W3048391025 title "O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes" @default.
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• W3048391025 doi "https://doi.org/10.1155/2020/5602396" @default.
• W3048391025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7439163" @default.
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