Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048686971> ?p ?o ?g. }
- W3048686971 endingPage "833" @default.
- W3048686971 startingPage "823" @default.
- W3048686971 abstract "Diabetes has been associated with increased COVID-19-related mortality, but the association between modifiable risk factors, including hyperglycaemia and obesity, and COVID-19-related mortality among people with diabetes is unclear. We assessed associations between risk factors and COVID-19-related mortality in people with type 1 and type 2 diabetes. We did a population-based cohort study of people with diagnosed diabetes who were registered with a general practice in England. National population data on people with type 1 and type 2 diabetes collated by the National Diabetes Audit were linked to mortality records collated by the Office for National Statistics from Jan 2, 2017, to May 11, 2020. We identified the weekly number of deaths in people with type 1 and type 2 diabetes during the first 19 weeks of 2020 and calculated the percentage change from the mean number of deaths for the corresponding weeks in 2017, 2018, and 2019. The associations between risk factors (including sex, age, ethnicity, socioeconomic deprivation, HbA1c, renal impairment [from estimated glomerular filtration rate (eGFR)], BMI, tobacco smoking status, and cardiovascular comorbidities) and COVID-19-related mortality (defined as International Classification of Diseases, version 10, code U07.1 or U07.2 as a primary or secondary cause of death) between Feb 16 and May 11, 2020, were investigated by use of Cox proportional hazards models. Weekly death registrations in the first 19 weeks of 2020 exceeded the corresponding 3-year weekly averages for 2017–19 by 672 (50·9%) in people with type 1 diabetes and 16 071 (64·3%) in people with type 2 diabetes. Between Feb 16 and May 11, 2020, among 264 390 people with type 1 diabetes and 2 874 020 people with type 2 diabetes, 1604 people with type 1 diabetes and 36 291 people with type 2 diabetes died from all causes. Of these total deaths, 464 in people with type 1 diabetes and 10 525 in people with type 2 diabetes were defined as COVID-19 related, of which 289 (62·3%) and 5833 (55·4%), respectively, occurred in people with a history of cardiovascular disease or with renal impairment (eGFR <60 mL/min per 1·73 m2). Male sex, older age, renal impairment, non-white ethnicity, socioeconomic deprivation, and previous stroke and heart failure were associated with increased COVID-19-related mortality in both type 1 and type 2 diabetes. Compared with people with an HbA1c of 48–53 mmol/mol (6·5–7·0%), people with an HbA1c of 86 mmol/mol (10·0%) or higher had increased COVID-19-related mortality (hazard ratio [HR] 2·23 [95% CI 1·50–3·30, p<0·0001] in type 1 diabetes and 1·61 [1·47–1·77, p<0·0001] in type 2 diabetes). In addition, in people with type 2 diabetes, COVID-19-related mortality was significantly higher in those with an HbA1c of 59 mmol/mol (7·6%) or higher than in those with an HbA1c of 48–53 mmol/mol (HR 1·22 [95% CI 1·15–1·30, p<0·0001] for 59–74 mmol/mol [7·6–8·9%] and 1·36 [1·24–1·50, p<0·0001] for 75–85 mmol/mol [9·0–9·9%]). The association between BMI and COVID-19-related mortality was U-shaped: in type 1 diabetes, compared with a BMI of 25·0–29·9 kg/m2, a BMI of less than 20·0 kg/m2 had an HR of 2·45 (95% CI 1·60–3·75, p<0·0001) and a BMI of 40·0 kg/m2 or higher had an HR of 2·33 (1·53–3·56, p<0·0001); the corresponding HRs for type 2 diabetes were 2·33 (2·11–2·56, p<0·0001) and 1·60 (1·47–1·75, p<0·0001). Deaths in people with type 1 and type 2 diabetes rose sharply during the initial COVID-19 pandemic in England. Increased COVID-19-related mortality was associated not only with cardiovascular and renal complications of diabetes but, independently, also with glycaemic control and BMI. None." @default.
- W3048686971 created "2020-08-18" @default.
- W3048686971 creator A5014611484 @default.
- W3048686971 creator A5017030033 @default.
- W3048686971 creator A5020857110 @default.
- W3048686971 creator A5023349584 @default.
- W3048686971 creator A5023619314 @default.
- W3048686971 creator A5038981967 @default.
- W3048686971 creator A5055869240 @default.
- W3048686971 creator A5056064808 @default.
- W3048686971 creator A5057904076 @default.
- W3048686971 creator A5062870643 @default.
- W3048686971 creator A5073213528 @default.
- W3048686971 creator A5078498803 @default.
- W3048686971 creator A5083222970 @default.
- W3048686971 date "2020-10-01" @default.
- W3048686971 modified "2023-10-11" @default.
- W3048686971 title "Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study" @default.
- W3048686971 cites W2029648873 @default.
- W3048686971 cites W2465777822 @default.
- W3048686971 cites W2567007802 @default.
- W3048686971 cites W2782746707 @default.
- W3048686971 cites W2886428084 @default.
- W3048686971 cites W3009885589 @default.
- W3048686971 cites W3011045397 @default.
- W3048686971 cites W3011439019 @default.
- W3048686971 cites W3014657680 @default.
- W3048686971 cites W3016370968 @default.
- W3048686971 cites W3017002108 @default.
- W3048686971 cites W3021684016 @default.
- W3048686971 cites W3022646285 @default.
- W3048686971 cites W3024432354 @default.
- W3048686971 cites W3024894164 @default.
- W3048686971 cites W3028583791 @default.
- W3048686971 cites W3031959493 @default.
- W3048686971 cites W3047144258 @default.
- W3048686971 cites W3048233329 @default.
- W3048686971 cites W3048704086 @default.
- W3048686971 doi "https://doi.org/10.1016/s2213-8587(20)30271-0" @default.
- W3048686971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7426091" @default.
- W3048686971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32798471" @default.
- W3048686971 hasPublicationYear "2020" @default.
- W3048686971 type Work @default.
- W3048686971 sameAs 3048686971 @default.
- W3048686971 citedByCount "634" @default.
- W3048686971 countsByYear W30486869712020 @default.
- W3048686971 countsByYear W30486869712021 @default.
- W3048686971 countsByYear W30486869712022 @default.
- W3048686971 countsByYear W30486869712023 @default.
- W3048686971 crossrefType "journal-article" @default.
- W3048686971 hasAuthorship W3048686971A5014611484 @default.
- W3048686971 hasAuthorship W3048686971A5017030033 @default.
- W3048686971 hasAuthorship W3048686971A5020857110 @default.
- W3048686971 hasAuthorship W3048686971A5023349584 @default.
- W3048686971 hasAuthorship W3048686971A5023619314 @default.
- W3048686971 hasAuthorship W3048686971A5038981967 @default.
- W3048686971 hasAuthorship W3048686971A5055869240 @default.
- W3048686971 hasAuthorship W3048686971A5056064808 @default.
- W3048686971 hasAuthorship W3048686971A5057904076 @default.
- W3048686971 hasAuthorship W3048686971A5062870643 @default.
- W3048686971 hasAuthorship W3048686971A5073213528 @default.
- W3048686971 hasAuthorship W3048686971A5078498803 @default.
- W3048686971 hasAuthorship W3048686971A5083222970 @default.
- W3048686971 hasBestOaLocation W30486869711 @default.
- W3048686971 hasConcept C126322002 @default.
- W3048686971 hasConcept C134018914 @default.
- W3048686971 hasConcept C144024400 @default.
- W3048686971 hasConcept C149923435 @default.
- W3048686971 hasConcept C179755657 @default.
- W3048686971 hasConcept C201903717 @default.
- W3048686971 hasConcept C2777180221 @default.
- W3048686971 hasConcept C2908647359 @default.
- W3048686971 hasConcept C50382708 @default.
- W3048686971 hasConcept C511355011 @default.
- W3048686971 hasConcept C555293320 @default.
- W3048686971 hasConcept C71924100 @default.
- W3048686971 hasConcept C72563966 @default.
- W3048686971 hasConcept C74909509 @default.
- W3048686971 hasConcept C99454951 @default.
- W3048686971 hasConceptScore W3048686971C126322002 @default.
- W3048686971 hasConceptScore W3048686971C134018914 @default.
- W3048686971 hasConceptScore W3048686971C144024400 @default.
- W3048686971 hasConceptScore W3048686971C149923435 @default.
- W3048686971 hasConceptScore W3048686971C179755657 @default.
- W3048686971 hasConceptScore W3048686971C201903717 @default.
- W3048686971 hasConceptScore W3048686971C2777180221 @default.
- W3048686971 hasConceptScore W3048686971C2908647359 @default.
- W3048686971 hasConceptScore W3048686971C50382708 @default.
- W3048686971 hasConceptScore W3048686971C511355011 @default.
- W3048686971 hasConceptScore W3048686971C555293320 @default.
- W3048686971 hasConceptScore W3048686971C71924100 @default.
- W3048686971 hasConceptScore W3048686971C72563966 @default.
- W3048686971 hasConceptScore W3048686971C74909509 @default.
- W3048686971 hasConceptScore W3048686971C99454951 @default.
- W3048686971 hasFunder F4320307758 @default.
- W3048686971 hasFunder F4320307765 @default.
- W3048686971 hasFunder F4320307778 @default.
- W3048686971 hasFunder F4320307781 @default.