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• W3080264953 abstract "The effects of Clostridium difficile toxin B on some actin-dependent functions of B lymphocytes were studied. A 3-day incubation of B lymphocytes with the toxin resulted in multinucleation in a similar manner to that seen after treatment with the microfilament-disrupting agent, cytochalasin B. The capping of IgM-receptors on U698 and Daudi cells was not inhibited by toxin B, whereas cytochalasin did inhibit capping. Using vimentin-negative Daudi cells, the cellular effects induced by toxin B were shown not to involve vimentin. The results suggest that toxin B inhibits formation of the actin-containing contractile ring needed in cytokinesis. Toxin B is the first bacterial protein toxin known to exert this effect." @default.
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• W3080264953 date "1990-03-01" @default.
• W3080264953 modified "2023-10-03" @default.
• W3080264953 title "Cellular Intoxication with <i>Clostridium Difficile</i> Toxin B" @default.
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• W3080264953 doi "https://doi.org/10.1177/026119299001700311" @default.
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