FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080413144> ?p ?o ?g. }

• W3080413144 endingPage "105059" @default.
• W3080413144 startingPage "105059" @default.
• W3080413144 abstract "There is a strong unmet need for translational progress towards Alzheimer's disease (AD) modifying therapy. Unfortunately, preclinical modeling of the disease has been disappointing, relying primarily on transgenic mouse overexpression of rare dominant mutations. Clinical manifestation of AD symptoms is known to reflect interaction between environmental and genetic risks. Mild traumatic brain injury (mTBI) is an environmental risk for dementia, including Alzheimer's, but there has been limited mechanistic analysis of mTBI contribution to AD. Here, we investigate the interplay between mTBI and Aβ precursor protein gene mutation in AD pathogenesis. We employed a knock-in (KI) model of AD that expresses the Aß-containing exons from human APP bearing the Swedish and Iberian mutations, namely AppNL-F/NL-F mice. Without environmental risk, this genetic variation yields minimal mouse symptomatology. Anesthetized 4-month-old KI mice and their age-matched wild type (WT) controls were subjected to repeated mild closed head injury (rmCHI), once daily for 14 days. Anesthetized, uninjured genotype- and age-matched mice were used as sham controls. At 3- and 8-months post-injury, amyloid-β, phospho-tau and Iba1 expression in the injured KI cortices were assessed. Our data reveal that rmCHI enhances accumulation of amyloid-β and hyperphosphorylated tau inclusions, as well as neuroinflammation in AppNL-F/NL-F mice. Furthermore, novel object recognition and Morris water maze tests demonstrated that rmCHI greatly exacerbates persistent cognitive deficits in APPNL-F/NL-F mice. Therefore, study of gene-environment interaction demonstrates that combining risk factors provides a more robust model for AD, and that repeated mTBI substantially accelerates AD pathology in a genetically susceptible situation." @default.
• W3080413144 created "2020-09-01" @default.
• W3080413144 creator A5013301564 @default.
• W3080413144 creator A5023317571 @default.
• W3080413144 creator A5026147594 @default.
• W3080413144 creator A5048441566 @default.
• W3080413144 creator A5086582786 @default.
• W3080413144 date "2020-11-01" @default.
• W3080413144 modified "2023-09-24" @default.
• W3080413144 title "Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in" @default.
• W3080413144 cites W1509460845 @default.
• W3080413144 cites W1535379795 @default.
• W3080413144 cites W1590917599 @default.
• W3080413144 cites W1725757145 @default.
• W3080413144 cites W195715187 @default.
• W3080413144 cites W1967061503 @default.
• W3080413144 cites W1967464880 @default.
• W3080413144 cites W1969979382 @default.
• W3080413144 cites W1972293239 @default.
• W3080413144 cites W1972468142 @default.
• W3080413144 cites W1973774127 @default.
• W3080413144 cites W1978118403 @default.
• W3080413144 cites W1980768099 @default.
• W3080413144 cites W1985345440 @default.
• W3080413144 cites W1990986671 @default.
• W3080413144 cites W1993120818 @default.
• W3080413144 cites W1999987205 @default.
• W3080413144 cites W2000350064 @default.
• W3080413144 cites W2005758956 @default.
• W3080413144 cites W2007158999 @default.
• W3080413144 cites W2011845342 @default.
• W3080413144 cites W2011949052 @default.
• W3080413144 cites W2028265367 @default.
• W3080413144 cites W2029904352 @default.
• W3080413144 cites W2034354239 @default.
• W3080413144 cites W2054640009 @default.
• W3080413144 cites W2056180446 @default.
• W3080413144 cites W2057035225 @default.
• W3080413144 cites W2057621671 @default.
• W3080413144 cites W2057766834 @default.
• W3080413144 cites W2061342941 @default.
• W3080413144 cites W2062084653 @default.
• W3080413144 cites W2062772621 @default.
• W3080413144 cites W2066350930 @default.
• W3080413144 cites W2067267561 @default.
• W3080413144 cites W2073009405 @default.
• W3080413144 cites W2081325915 @default.
• W3080413144 cites W2090020945 @default.
• W3080413144 cites W2090150925 @default.
• W3080413144 cites W2090620788 @default.
• W3080413144 cites W2092345297 @default.
• W3080413144 cites W2092466014 @default.
• W3080413144 cites W2098731968 @default.
• W3080413144 cites W2099180554 @default.
• W3080413144 cites W2101077392 @default.
• W3080413144 cites W2106837589 @default.
• W3080413144 cites W2107447135 @default.
• W3080413144 cites W2111433735 @default.
• W3080413144 cites W2116016048 @default.
• W3080413144 cites W2121948289 @default.
• W3080413144 cites W2124994926 @default.
• W3080413144 cites W2128358339 @default.
• W3080413144 cites W2133647554 @default.
• W3080413144 cites W2134478490 @default.
• W3080413144 cites W2138878035 @default.
• W3080413144 cites W2141679195 @default.
• W3080413144 cites W2142943752 @default.
• W3080413144 cites W2146250230 @default.
• W3080413144 cites W2153026104 @default.
• W3080413144 cites W2153779246 @default.
• W3080413144 cites W2153945143 @default.
• W3080413144 cites W2170644095 @default.
• W3080413144 cites W2274863439 @default.
• W3080413144 cites W2329336071 @default.
• W3080413144 cites W2331509664 @default.
• W3080413144 cites W2393736817 @default.
• W3080413144 cites W2414194618 @default.
• W3080413144 cites W2552566442 @default.
• W3080413144 cites W2588078287 @default.
• W3080413144 cites W2605212557 @default.
• W3080413144 cites W2606208444 @default.
• W3080413144 cites W2606481147 @default.
• W3080413144 cites W2730829886 @default.
• W3080413144 cites W2738207153 @default.
• W3080413144 cites W2743008549 @default.
• W3080413144 cites W2747754519 @default.
• W3080413144 cites W2766901297 @default.
• W3080413144 cites W2767813783 @default.
• W3080413144 cites W2773820111 @default.
• W3080413144 cites W2799831564 @default.
• W3080413144 cites W2802445858 @default.
• W3080413144 cites W2805059432 @default.
• W3080413144 cites W2809494109 @default.
• W3080413144 cites W2866827747 @default.
• W3080413144 cites W2888450536 @default.
• W3080413144 cites W2889787710 @default.
• W3080413144 cites W2890539199 @default.
• W3080413144 cites W2897658623 @default.

• next