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- W3080494549 endingPage "287" @default.
- W3080494549 startingPage "273" @default.
- W3080494549 abstract "The proteasome is a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells that controls numerous cellular processes through regulated protein degradation. Proteasome inhibitors have significantly improved the survival of multiple myeloma patients. However, clinically approved proteasome inhibitors have failed to show efficacy against solid tumors, neither alone nor in combination with other therapies. Targeting the immunoproteasome with selective inhibitors has been therapeutically effective in preclinical models for several autoimmune diseases and colon cancer. Moreover, immunoproteasome inhibitors prevented the chronic rejection of allogeneic organ transplants. In recent years, it has become apparent that inhibition of one single active center of the proteasome is insufficient to achieve therapeutic benefits. In this review we summarize the latest insights how targeting multiple catalytically active proteasome subunits can interfere with disease progression in autoimmunity, growth of solid tumors, and allograft rejection." @default.
- W3080494549 created "2020-09-01" @default.
- W3080494549 creator A5001660126 @default.
- W3080494549 creator A5023085770 @default.
- W3080494549 date "2020-08-25" @default.
- W3080494549 modified "2023-10-11" @default.
- W3080494549 title "Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy" @default.
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