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- W3086311092 endingPage "1064" @default.
- W3086311092 startingPage "1064" @default.
- W3086311092 abstract "Aspergilli have been widely used in the production of organic acids, enzymes, and secondary metabolites for almost a century. Today, several GRAS (generally recognized as safe) Aspergillus species hold a central role in the field of industrial biotechnology with multiple profitable applications. Since the 1990s, research has focused on the use of Aspergillus species in the development of cell factories for the production of recombinant proteins mainly due to their natively high secretion capacity. Advances in the Aspergillus-specific molecular toolkit and combination of several engineering strategies (e.g., protease-deficient strains and fusions to carrier proteins) resulted in strains able to generate high titers of recombinant fungal proteins. However, the production of non-fungal proteins appears to still be inefficient due to bottlenecks in fungal expression and secretion machinery. After a brief overview of the different heterologous expression systems currently available, this review focuses on the filamentous fungi belonging to the genus Aspergillus and their use in recombinant protein production. We describe key steps in protein synthesis and secretion that may limit production efficiency in Aspergillus systems and present genetic engineering approaches and bioprocessing strategies that have been adopted in order to improve recombinant protein titers and expand the potential of Aspergilli as competitive production platforms." @default.
- W3086311092 created "2020-09-21" @default.
- W3086311092 creator A5003461054 @default.
- W3086311092 creator A5035694865 @default.
- W3086311092 creator A5054962508 @default.
- W3086311092 creator A5081898951 @default.
- W3086311092 date "2020-09-16" @default.
- W3086311092 modified "2023-10-14" @default.
- W3086311092 title "Aspergillus: A Powerful Protein Production Platform" @default.
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