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• W3088896952 abstract "Female fertility relies on successful egg development. Besides chromosome segregation, complex structural and biochemical changes in the cytoplasmic compartment are necessary to confer the female gamete the capacity to undergo normal fertilization and sustain embryonic development. Despite the profound impact on egg quality, morphological bases of cytoplasmic maturation remain largely unknown. Here, we report our findings from the ultrastructural analysis of 69 unfertilized human oocytes from 34 young and healthy egg donors. By comparison of samples fixed at three consecutive developmental stages, we explored how ooplasmic architecture changes during meiotic maturation in vitro. The morphometric image analysis supported observation that the major reorganization of cytoplasm occurs before polar body extrusion. The organelles initially concentrated around prophase nucleus were repositioned toward the periphery and evenly distributed throughout the ooplasm. As maturation progressed, distinct secretory apparatus appeared to transform into cortical granules that clustered underneath the oocyte's surface. The most prominent feature was the gradual formation of heterologous complexes composed of variable elements of endoplasmic reticulum and multiple mitochondria with primitive morphology. Based on the generated image dataset, we proposed a morphological map of cytoplasmic maturation, which may serve as a reference for future comparative studies. In conclusion, this work improves our understanding of human oocyte morphology, cytoplasmic maturation, and intracellular factors defining human egg quality. Although this analysis involved spare oocytes completing development in vitro, it provides essential insight into the enigmatic process by which human egg progenitors prepare for fertilization." @default.
• W3088896952 created "2020-10-01" @default.
• W3088896952 creator A5030063705 @default.
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• W3088896952 date "2020-09-21" @default.
• W3088896952 modified "2023-10-17" @default.
• W3088896952 title "Cytoplasmic maturation in human oocytes: an ultrastructural study †" @default.
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• W3088896952 doi "https://doi.org/10.1093/biolre/ioaa174" @default.
• W3088896952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7786262" @default.
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• W3088896952 hasPublicationYear "2020" @default.
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