FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3090218118> ?p ?o ?g. }

• W3090218118 endingPage "260" @default.
• W3090218118 startingPage "252" @default.
• W3090218118 abstract "Background: Epileptic seizures affect the life of noticeable number of people in all over the world. Tanacetum parthenium (TP) is used in traditional medicine. We studied the effects of hydro- ethanolic extract of TP and its n-butanol and aqueous fractions on brain oxidative damage in pentylenetetrazole (PTZ)-induced seizures in mice. Methods: Male mice were divided into: (1) Control; (2) PTZ (100 mg/kg, i.p.); (3-5) hydro-ethanolic extract of TP (50, 100 and 200 mg/kg); (6) n-butanol (NBut) (100 mg/kg) and (7) aqueous (Aq) (100 mg/kg) fractions. Extracts were injected (i.p.) for 3 days and 30 min before PTZ. Latencies in onset of Minimal Clonic Seizures (MCS) and Generalized Tonic-Clonic Seizures (GTCS) as well as biochemical indicators were evaluated. Results: Medium dose of TP extract and NBut fraction prolonged the MSC and GTCS latencies. Biochemical data confirmed that administration of hydro-ethanolic extract of TP significantly reduced MDA and enhanced total thiol content and the activity of SOD and CAT in brain tissues. Comparison the effect of NBut and Aq fractions with medium dose indicated a higher level of MDA and lower amount of total thiol content and the activity of SOD and CAT in brain tissues of PTZ-Aq100 and PTZ-NBut100 groups than PTZ-TP100 group. Results: demonstrated that the medium dose of TP extract had the most protective effect against brain oxidative damage in PTZ-induced seizure model. N-butanol and aqueous fractions of TP could not exert stronger effect than medium dose on reduction PTZ-induced brain oxidative stress. Results: Medium dose of TP extract and NBut fraction prolonged the MSC and GTCS latencies. Biochemical data confirmed that administration of hydro-ethanolic extract of TP significantly reduced MDA and enhanced total thiol content and the activity of SOD and CAT in brain tissues. Comparison the effect of NBut and Aq fractions with medium dose indicated a higher level of MDA and lower amount of total thiol content and the activity of SOD and CAT in brain tissues of PTZ-Aq100 and PTZ-NBut100 groups than PTZ-TP100 group. Conclusion: Results demonstrated that the medium dose of TP extract had the most protective effect against brain oxidative damage in PTZ-induced seizure model. N-butanol and aqueous fractions of TP could not exert stronger effect than medium dose on reduction PTZ-induced brain oxidative stress." @default.
• W3090218118 created "2020-10-08" @default.
• W3090218118 creator A5005277756 @default.
• W3090218118 creator A5017311650 @default.
• W3090218118 creator A5039820838 @default.
• W3090218118 creator A5042901205 @default.
• W3090218118 creator A5048547583 @default.
• W3090218118 creator A5049455509 @default.
• W3090218118 creator A5078645015 @default.
• W3090218118 creator A5081215156 @default.
• W3090218118 creator A5089673351 @default.
• W3090218118 date "2020-09-20" @default.
• W3090218118 modified "2023-10-11" @default.
• W3090218118 title "Effects of Hydro-ethanolic Extract of <i>Tanacetum parthenium</i> and its N-Butanol and Aqueous Fractions on Brain Oxidative Damage in Pentylenetetrazole-Induced Seizures in Mice" @default.
• W3090218118 cites W1554632349 @default.
• W3090218118 cites W1920696238 @default.
• W3090218118 cites W1966259921 @default.
• W3090218118 cites W1969109023 @default.
• W3090218118 cites W1970310065 @default.
• W3090218118 cites W1988371755 @default.
• W3090218118 cites W1993880151 @default.
• W3090218118 cites W2038445303 @default.
• W3090218118 cites W2040153029 @default.
• W3090218118 cites W2054287580 @default.
• W3090218118 cites W2081919360 @default.
• W3090218118 cites W2087764950 @default.
• W3090218118 cites W2104500707 @default.
• W3090218118 cites W2122648659 @default.
• W3090218118 cites W2149088071 @default.
• W3090218118 cites W2158338571 @default.
• W3090218118 cites W2160278873 @default.
• W3090218118 cites W2172934983 @default.
• W3090218118 cites W2554548393 @default.
• W3090218118 cites W2583513347 @default.
• W3090218118 cites W2617727559 @default.
• W3090218118 cites W2625134419 @default.
• W3090218118 cites W2702374653 @default.
• W3090218118 cites W2751080201 @default.
• W3090218118 cites W2768043581 @default.
• W3090218118 cites W2769621691 @default.
• W3090218118 cites W2779151730 @default.
• W3090218118 cites W2784781506 @default.
• W3090218118 cites W2791893982 @default.
• W3090218118 cites W2807544625 @default.
• W3090218118 cites W2885236605 @default.
• W3090218118 cites W2899332685 @default.
• W3090218118 cites W2899932248 @default.
• W3090218118 cites W2911314520 @default.
• W3090218118 cites W2911721148 @default.
• W3090218118 cites W2914230244 @default.
• W3090218118 cites W2923673415 @default.
• W3090218118 cites W2935748707 @default.
• W3090218118 cites W2938388868 @default.
• W3090218118 cites W2941203287 @default.
• W3090218118 cites W2942591730 @default.
• W3090218118 cites W2945584547 @default.
• W3090218118 doi "https://doi.org/10.34172/ps.2020.32" @default.
• W3090218118 hasPublicationYear "2020" @default.
• W3090218118 type Work @default.
• W3090218118 sameAs 3090218118 @default.
• W3090218118 citedByCount "1" @default.
• W3090218118 countsByYear W30902181182022 @default.
• W3090218118 crossrefType "journal-article" @default.
• W3090218118 hasAuthorship W3090218118A5005277756 @default.
• W3090218118 hasAuthorship W3090218118A5017311650 @default.
• W3090218118 hasAuthorship W3090218118A5039820838 @default.
• W3090218118 hasAuthorship W3090218118A5042901205 @default.
• W3090218118 hasAuthorship W3090218118A5048547583 @default.
• W3090218118 hasAuthorship W3090218118A5049455509 @default.
• W3090218118 hasAuthorship W3090218118A5078645015 @default.
• W3090218118 hasAuthorship W3090218118A5081215156 @default.
• W3090218118 hasAuthorship W3090218118A5089673351 @default.
• W3090218118 hasBestOaLocation W30902181181 @default.
• W3090218118 hasConcept C178790620 @default.
• W3090218118 hasConcept C184651966 @default.
• W3090218118 hasConcept C185592680 @default.
• W3090218118 hasConcept C2776151105 @default.
• W3090218118 hasConcept C2777713963 @default.
• W3090218118 hasConcept C2780021418 @default.
• W3090218118 hasConcept C2780161600 @default.
• W3090218118 hasConcept C3020296196 @default.
• W3090218118 hasConcept C55493867 @default.
• W3090218118 hasConcept C556039675 @default.
• W3090218118 hasConcept C57600042 @default.
• W3090218118 hasConcept C71924100 @default.
• W3090218118 hasConcept C98274493 @default.
• W3090218118 hasConceptScore W3090218118C178790620 @default.
• W3090218118 hasConceptScore W3090218118C184651966 @default.
• W3090218118 hasConceptScore W3090218118C185592680 @default.
• W3090218118 hasConceptScore W3090218118C2776151105 @default.
• W3090218118 hasConceptScore W3090218118C2777713963 @default.
• W3090218118 hasConceptScore W3090218118C2780021418 @default.
• W3090218118 hasConceptScore W3090218118C2780161600 @default.
• W3090218118 hasConceptScore W3090218118C3020296196 @default.
• W3090218118 hasConceptScore W3090218118C55493867 @default.
• W3090218118 hasConceptScore W3090218118C556039675 @default.
• W3090218118 hasConceptScore W3090218118C57600042 @default.
• W3090218118 hasConceptScore W3090218118C71924100 @default.

• next