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• W3091912917 abstract "Background Quantification of myocardial blood flow (MBF) from dynamic contrast‐enhanced (DCE) MRI can be performed using a signal intensity model that incorporates T 1 values of blood and myocardium. Purpose To assess the impact of T 1 values on pixelwise MBF quantification, specifically to evaluate the influence of 1) study population‐averaged vs. subject‐specific, 2) diastolic vs. systolic, and 3) regional vs. global myocardial T 1 values. Study Type Prospective. Subjects Fifteen patients with chronic coronary heart disease. Field Strength/Sequence 3T; modified Look–Locker inversion recovery for T 1 mapping and saturation recovery gradient echo for DCE imaging, both acquired in a mid‐ventricular short‐axis slice in systole and diastole. Assessment MBF was estimated using Fermi modeling and signal intensity nonlinearity correction with different T 1 values: study population‐averaged blood and myocardial, subject‐specific systolic and diastolic, and segmental T 1 values. Myocardial segments with perfusion deficits were identified visually from DCE series. Statistical Tests The relationships between MBF parameters derived by different methods were analyzed by Bland–Altman analysis; corresponding mean values were compared by t ‐test. Results Using subject‐specific diastolic T 1 values, global diastolic MBF was 0.61 ± 0.13 mL/(min·g). It did not differ from global MBF derived from the study population‐averaged T 1 ( P = 0.88), but the standard deviation of differences was large (0.07 mL/(min·g), 11% of mean MBF). Global diastolic and systolic MBF did not differ ( P = 0.12), whereas global diastolic MBF using systolic (0.62 ± 0.13 mL/(min·g)) and diastolic T 1 values differed ( P < 0.05). If regional instead of global T 1 values were used, segmental MBF was lower in segments with perfusion deficits (bias = −0.03 mL/(min·g), −7% of mean MBF, P < 0.05) but higher in segments without perfusion deficits (bias = 0.01 mL/(min·g), 1% of mean MBF, P < 0.05). Data Conclusion Whereas cardiac phase‐specific T 1 values have a minor impact on MBF estimates, subject‐specific and myocardial segment‐specific T 1 values substantially affect MBF quantification. Level of Evidence 3 Technical Efficacy Stage 3" @default.
• W3091912917 created "2020-10-15" @default.
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• W3091912917 date "2020-10-08" @default.
• W3091912917 modified "2023-10-18" @default.
• W3091912917 title "Impact of the Choice of Native T 1 in Pixelwise Myocardial Blood Flow Quantification" @default.
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• W3091912917 doi "https://doi.org/10.1002/jmri.27375" @default.
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