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- W3092288892 abstract "The substitution of the seventeenth amino acid glutamate by lysine in the homologous structural domain of the Akt1 gene pleckstrin is a somatic cellular mutation found in breast, colorectal and ovarian cancers, named p. Glu17Lys or E17K. In recent years, a growing number of studies have suggested that this mutation may play a unique role in the development of tumors. In this review article, we describe how AKT1(E17K) mutations stimulate downstream signals that cause cells to emerge transformed; we explore the differential regulation and function of E17K in different physiological and pathological settings; and we also describe the phenomenon that E17K impedes tumor growth by interfering with growth-promoting and chemotherapy-resistant AKT1lowQCC generation, an intriguing finding that mutants may prolong tumor patient survival by activating feedback mechanisms and disrupting transcription. This review is intended to provide a better understanding of the role of AKT1(E17K) in cancer and to inform the development of AKT1(E17K)-based antitumor strategies." @default.
- W3092288892 created "2020-10-15" @default.
- W3092288892 creator A5006436046 @default.
- W3092288892 creator A5007708850 @default.
- W3092288892 creator A5010599695 @default.
- W3092288892 creator A5040558103 @default.
- W3092288892 creator A5058074481 @default.
- W3092288892 creator A5069811393 @default.
- W3092288892 creator A5070754234 @default.
- W3092288892 date "2020-10-06" @default.
- W3092288892 modified "2023-09-23" @default.
- W3092288892 title "Effect of AKT1 (p. E17K) Hotspot Mutation on Malignant Tumorigenesis and Prognosis" @default.
- W3092288892 cites W1500729563 @default.
- W3092288892 cites W1761753578 @default.
- W3092288892 cites W1810305144 @default.
- W3092288892 cites W1876597264 @default.
- W3092288892 cites W1893137636 @default.
- W3092288892 cites W1963912235 @default.
- W3092288892 cites W1972590376 @default.
- W3092288892 cites W1973425911 @default.
- W3092288892 cites W1977223602 @default.
- W3092288892 cites W1977267072 @default.
- W3092288892 cites W1980705784 @default.
- W3092288892 cites W1981517713 @default.
- W3092288892 cites W1982395176 @default.
- W3092288892 cites W1985046929 @default.
- W3092288892 cites W1989116783 @default.
- W3092288892 cites W1989141849 @default.
- W3092288892 cites W1991611148 @default.
- W3092288892 cites W1994917415 @default.
- W3092288892 cites W1995117011 @default.
- W3092288892 cites W1995482311 @default.
- W3092288892 cites W1996695017 @default.
- W3092288892 cites W1996872884 @default.
- W3092288892 cites W1997767485 @default.
- W3092288892 cites W2003406618 @default.
- W3092288892 cites W2004019185 @default.
- W3092288892 cites W2005715029 @default.
- W3092288892 cites W2006148253 @default.
- W3092288892 cites W2009007518 @default.
- W3092288892 cites W2009364489 @default.
- W3092288892 cites W2010190071 @default.
- W3092288892 cites W2014169920 @default.
- W3092288892 cites W2015813074 @default.
- W3092288892 cites W2018023891 @default.
- W3092288892 cites W2018326393 @default.
- W3092288892 cites W2019974241 @default.
- W3092288892 cites W2020099265 @default.
- W3092288892 cites W2025002326 @default.
- W3092288892 cites W2030977583 @default.
- W3092288892 cites W2034269086 @default.
- W3092288892 cites W2037591877 @default.
- W3092288892 cites W2044182846 @default.
- W3092288892 cites W2046867705 @default.
- W3092288892 cites W2048228826 @default.
- W3092288892 cites W2050182646 @default.
- W3092288892 cites W2052654080 @default.
- W3092288892 cites W2054340362 @default.
- W3092288892 cites W2056183265 @default.
- W3092288892 cites W2056206005 @default.
- W3092288892 cites W2056982291 @default.
- W3092288892 cites W2057215600 @default.
- W3092288892 cites W2057449864 @default.
- W3092288892 cites W2061673659 @default.
- W3092288892 cites W2061769845 @default.
- W3092288892 cites W2063550022 @default.
- W3092288892 cites W2064353818 @default.
- W3092288892 cites W2065674479 @default.
- W3092288892 cites W2068025786 @default.
- W3092288892 cites W2072697288 @default.
- W3092288892 cites W2080100938 @default.
- W3092288892 cites W2083762829 @default.
- W3092288892 cites W2086651571 @default.
- W3092288892 cites W2087250619 @default.
- W3092288892 cites W2087861588 @default.
- W3092288892 cites W2091403769 @default.
- W3092288892 cites W2092000556 @default.
- W3092288892 cites W2094438068 @default.
- W3092288892 cites W2094709780 @default.
- W3092288892 cites W2101297236 @default.
- W3092288892 cites W2106036365 @default.
- W3092288892 cites W2117962815 @default.
- W3092288892 cites W2123324945 @default.
- W3092288892 cites W2126783165 @default.
- W3092288892 cites W2130981598 @default.
- W3092288892 cites W2131677957 @default.
- W3092288892 cites W2132399579 @default.
- W3092288892 cites W2134602357 @default.
- W3092288892 cites W2136070754 @default.
- W3092288892 cites W2141633072 @default.
- W3092288892 cites W2142837526 @default.
- W3092288892 cites W2147114673 @default.
- W3092288892 cites W2147941657 @default.
- W3092288892 cites W2149443458 @default.
- W3092288892 cites W2149703329 @default.
- W3092288892 cites W2152654745 @default.
- W3092288892 cites W2155228605 @default.
- W3092288892 cites W2156063202 @default.
- W3092288892 cites W2162527783 @default.
- W3092288892 cites W2169128676 @default.