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- W3100565516 abstract "Significance Here, we demonstrate that CSA and CSB proteins, primarily defined as DNA repair factors, are part of a ubiquitin/proteasome degradation process during cytokinesis. Both CSA and CSB localize at the midbody, a transient structure located at the intercellular bridge, where they recruit a ubiquitination/proteasomal degradation complex for the degradation of PRC1, thus allowing the separation of the daughter cells. Defects in CSA or CSB result in perturbation of the abscission, leading to cytokinesis defects that might explain part of the Cockayne syndrome phenotypes. Our results enlighten the role played by CSA and CSB in a ubiquitin/proteasome degradation process involved not only in transcription and DNA repair, but also in cell division." @default.
- W3100565516 created "2020-11-23" @default.
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- W3100565516 date "2020-11-16" @default.
- W3100565516 modified "2023-10-14" @default.
- W3100565516 title "The Cockayne syndrome group A and B proteins are part of a ubiquitin–proteasome degradation complex regulating cell division" @default.
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- W3100565516 doi "https://doi.org/10.1073/pnas.2006543117" @default.
- W3100565516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7720219" @default.
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