FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3110367443> ?p ?o ?g. }

• W3110367443 abstract "Currently, there is no effective treatment for premature ovarian failure (POF), and stem cell therapy is considered the most promising treatment. Human umbilical cord blood mesenchymal stem cells (hUC-MSCs) have shown good regenerative ability in various diseases, including POF; however, their underlying mechanism and dosage for POF treatment remain unclear. This study aimed to compare the effect of single and multiple injections of hUC-MSCs on ovarian function repair in chemotherapy-induced POF.Female mice were intraperitoneally injected with 30 mg/kg busulfan and 120 mg/kg cyclophosphamide (CTX) to induce POF. In the single hUC-MSC injection group, hUC-MSCs were transplanted into mice D7 after CTX and busulfan administration, while in the multiple injection group, hUC-MSCs were transplanted on D7, D14, and D21 after CTX and busulfan administration. We evaluated the ovarian morphology, fertility, follicle-stimulating hormone and estradiol concentrations, follicle count, POF model, and cell transplantation results. In addition, real-time polymerase chain reaction, immunohistochemistry, and miRNA and mRNA chips were used to evaluate the effect of the cell therapy.Ovary size, number of follicle at all developmental stages, and fertility were significantly reduced in the POF group compared with the control. Under hUC-MSC treatment, the ovarian morphology and follicle count were significantly restored, and fertility was significantly increased. By comparing the single and multiple hUC-MSC injection groups, we found that the anti-Müllerian hormone and Ki-67 levels were significantly increased in the multiple hUC-MSC group on D60 after chemotherapy. The expression of stimulating hormone receptors, inhibin α, and inhibin β was significantly restored, and the therapeutic effect was superior to that of the single hUC-MSC injection group.These results indicate that hUC-MSCs can restore the structure of injured ovarian tissue and its function in chemotherapy-induced POF mice and ameliorate fertility. Multiple hUC-MSC transplantations have a better effect on the recovery of ovarian function than single hUC-MSC transplantation in POF." @default.
• W3110367443 created "2020-12-07" @default.
• W3110367443 creator A5007989942 @default.
• W3110367443 creator A5018168958 @default.
• W3110367443 creator A5019726673 @default.
• W3110367443 creator A5032929941 @default.
• W3110367443 creator A5033887031 @default.
• W3110367443 creator A5044757881 @default.
• W3110367443 creator A5051025753 @default.
• W3110367443 creator A5060002817 @default.
• W3110367443 date "2021-09-15" @default.
• W3110367443 modified "2023-09-27" @default.
• W3110367443 title "Effects of single and multiple transplantations of human umbilical cord mesenchymal stem cells on the recovery of ovarian function in the treatment of premature ovarian failure in mice" @default.
• W3110367443 cites W1648441294 @default.
• W3110367443 cites W1967612002 @default.
• W3110367443 cites W1971639545 @default.
• W3110367443 cites W1976470213 @default.
• W3110367443 cites W2003887958 @default.
• W3110367443 cites W2008594958 @default.
• W3110367443 cites W2035809865 @default.
• W3110367443 cites W2036348189 @default.
• W3110367443 cites W2039031583 @default.
• W3110367443 cites W2043264689 @default.
• W3110367443 cites W2047482152 @default.
• W3110367443 cites W2054035555 @default.
• W3110367443 cites W2127738960 @default.
• W3110367443 cites W2150947445 @default.
• W3110367443 cites W2158048826 @default.
• W3110367443 cites W2162433799 @default.
• W3110367443 cites W2163057165 @default.
• W3110367443 cites W2228158019 @default.
• W3110367443 cites W2237376052 @default.
• W3110367443 cites W2301597926 @default.
• W3110367443 cites W2313799234 @default.
• W3110367443 cites W2505550239 @default.
• W3110367443 cites W2514216329 @default.
• W3110367443 cites W2564194415 @default.
• W3110367443 cites W2587397947 @default.
• W3110367443 cites W2611957270 @default.
• W3110367443 cites W2746710261 @default.
• W3110367443 cites W2770384049 @default.
• W3110367443 cites W2787076351 @default.
• W3110367443 cites W2799453916 @default.
• W3110367443 cites W2887061063 @default.
• W3110367443 cites W2896017670 @default.
• W3110367443 cites W2906270235 @default.
• W3110367443 cites W2920123672 @default.
• W3110367443 cites W2922078985 @default.
• W3110367443 cites W2935946042 @default.
• W3110367443 cites W2950854031 @default.
• W3110367443 cites W2972946432 @default.
• W3110367443 cites W2974331394 @default.
• W3110367443 cites W2982686492 @default.
• W3110367443 cites W2989757496 @default.
• W3110367443 cites W2990955628 @default.
• W3110367443 cites W2991153025 @default.
• W3110367443 cites W3037614810 @default.
• W3110367443 cites W3047139656 @default.
• W3110367443 cites W3085783016 @default.
• W3110367443 cites W3093087297 @default.
• W3110367443 cites W3114786268 @default.
• W3110367443 cites W3130870680 @default.
• W3110367443 cites W4242495675 @default.
• W3110367443 cites W4243396486 @default.
• W3110367443 doi "https://doi.org/10.1186/s13048-021-00871-4" @default.
• W3110367443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8442267" @default.
• W3110367443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34526090" @default.
• W3110367443 hasPublicationYear "2021" @default.
• W3110367443 type Work @default.
• W3110367443 sameAs 3110367443 @default.
• W3110367443 citedByCount "11" @default.
• W3110367443 countsByYear W31103674432022 @default.
• W3110367443 countsByYear W31103674432023 @default.
• W3110367443 crossrefType "journal-article" @default.
• W3110367443 hasAuthorship W3110367443A5007989942 @default.
• W3110367443 hasAuthorship W3110367443A5018168958 @default.
• W3110367443 hasAuthorship W3110367443A5019726673 @default.
• W3110367443 hasAuthorship W3110367443A5032929941 @default.
• W3110367443 hasAuthorship W3110367443A5033887031 @default.
• W3110367443 hasAuthorship W3110367443A5044757881 @default.
• W3110367443 hasAuthorship W3110367443A5051025753 @default.
• W3110367443 hasAuthorship W3110367443A5060002817 @default.
• W3110367443 hasBestOaLocation W31103674431 @default.
• W3110367443 hasConcept C102570824 @default.
• W3110367443 hasConcept C126322002 @default.
• W3110367443 hasConcept C134018914 @default.
• W3110367443 hasConcept C142724271 @default.
• W3110367443 hasConcept C16685009 @default.
• W3110367443 hasConcept C179933525 @default.
• W3110367443 hasConcept C196843134 @default.
• W3110367443 hasConcept C198826908 @default.
• W3110367443 hasConcept C203014093 @default.
• W3110367443 hasConcept C2776600139 @default.
• W3110367443 hasConcept C2776955114 @default.
• W3110367443 hasConcept C2777395788 @default.
• W3110367443 hasConcept C2777408962 @default.
• W3110367443 hasConcept C2777688143 @default.
• W3110367443 hasConcept C2777904497 @default.
• W3110367443 hasConcept C2778324911 @default.
• W3110367443 hasConcept C2778780466 @default.

• next