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• W3112244676 endingPage "466" @default.
• W3112244676 startingPage "466" @default.
• W3112244676 abstract "During circuit assembly it is essential that neurons connect with their specific synaptic partners. To facilitate this process, a common strategy in many organisms is the organization of brain regions, including the fly visual system, in layers and columns. The atypical-cadherin Flamingo (Fmi) and the receptor Golden Goal (Gogo) were proposed to regulate both the temporary and final layer selection of the R8 photoreceptor, through the cytoplasmic domain of Gogo. Our data suggests that Fmi intracellular signaling is also relevant for R8 final layer selection. The LIM-domain cytoplasmic molecule Espinas (Esn) binds Fmi, and they cooperatively control dendritic self-avoidance in sensory neurons. We observed defects in R8 layer selection in esn mutants with axons overshooting the final target layer, and we demonstrated that the LIM domain is necessary for layer selection. fmi knockdown in photoreceptors results in most R8 axons stalling at the temporary layer, however, we also detected R8 axons projecting past the final-target layer, and showed that fmi and esn genetically interact. Based on the previously described physical and genetic interactions between Fmi/Esn and the findings presented here, we propose that Esn signals downstream of Fmi to stabilize R8 axons in their final target layer." @default.
• W3112244676 created "2020-12-21" @default.
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• W3112244676 date "2020-12-14" @default.
• W3112244676 modified "2023-10-15" @default.
• W3112244676 title "The Cytoplasmic LIM Domain Protein Espinas Contributes to Photoreceptor Layer Selection in the Visual System" @default.
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• W3112244676 doi "https://doi.org/10.3390/biology9120466" @default.
• W3112244676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7764898" @default.
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• W3112244676 hasPublicationYear "2020" @default.
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