FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3113175062> ?p ?o ?g. }

• W3113175062 endingPage "534" @default.
• W3113175062 startingPage "523" @default.
• W3113175062 abstract "Colorectal cancer (CRC) is a common cancer worldwide, and its treatment strategies are limited. The underlying mechanism of CRC progression remains to be determined. Telomere maintenance 2 (TELO2) is a mTOR‑interacting protein. Both the role and molecular mechanism of TELO2 in cancer progression remain unknown. In this study, the gene expression database of normal and tumor tissue, in addition to western blot analysis, and immunohistochemistry (IHC) were used to determine the expression and location of TELO2 in CRC and normal tissues. Clinical features of a tissue array were collected and analyzed. WST‑1, soft agar, flow cytometry, wound healing, and invasion assays were employed to verify the role of TELO2 in the growth, cell cycle, migration, and invasion of CRC cells. The correlation between TELO2 and RICTOR (rapamycin‑insensitive companion of mTOR) was analyzed by bioinformatics, IHC, and immunoprecipitation. Normal and serum‑deprived cells were collected to detect the protein level of TELO2 and its downstream effectors. The results revealed that TELO2 was significantly upregulated in CRC, and TELO2 inhibition significantly restrained the growth, cell cycle, and metastasis of CRC cells. TELO2 overexpression correlated with age, lymph node metastasis, and TNM stage of CRC patients. In addition, TELO2 was positively correlated with RICTOR in CRC and induced tumor progression mainly via RICTOR with serum in culture. RICTOR induced the degradation of TELO2 upon serum deprivation in an mTOR‑independent manner. These findings indicate that TELO2 promotes tumor progression via RICTOR in a serum‑dependent manner, which may be a potential therapeutic target for CRC." @default.
• W3113175062 created "2020-12-21" @default.
• W3113175062 creator A5017530435 @default.
• W3113175062 creator A5018148936 @default.
• W3113175062 creator A5023755501 @default.
• W3113175062 creator A5024727288 @default.
• W3113175062 creator A5038694564 @default.
• W3113175062 creator A5057063084 @default.
• W3113175062 creator A5064657543 @default.
• W3113175062 creator A5071773009 @default.
• W3113175062 creator A5083019914 @default.
• W3113175062 creator A5085661325 @default.
• W3113175062 creator A5087055335 @default.
• W3113175062 date "2020-12-09" @default.
• W3113175062 modified "2023-10-06" @default.
• W3113175062 title "TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2" @default.
• W3113175062 cites W1601840114 @default.
• W3113175062 cites W1861089690 @default.
• W3113175062 cites W1884356516 @default.
• W3113175062 cites W1970473600 @default.
• W3113175062 cites W1975643648 @default.
• W3113175062 cites W1978670320 @default.
• W3113175062 cites W2057975188 @default.
• W3113175062 cites W2073075035 @default.
• W3113175062 cites W2077798795 @default.
• W3113175062 cites W2100535647 @default.
• W3113175062 cites W2117347105 @default.
• W3113175062 cites W2122573477 @default.
• W3113175062 cites W2134058393 @default.
• W3113175062 cites W2214198121 @default.
• W3113175062 cites W2432914987 @default.
• W3113175062 cites W2578248437 @default.
• W3113175062 cites W2587669016 @default.
• W3113175062 cites W2593816418 @default.
• W3113175062 cites W2606513998 @default.
• W3113175062 cites W2611174399 @default.
• W3113175062 cites W2624938913 @default.
• W3113175062 cites W2755519263 @default.
• W3113175062 cites W2788185610 @default.
• W3113175062 cites W2792523396 @default.
• W3113175062 cites W2811106767 @default.
• W3113175062 cites W2911188335 @default.
• W3113175062 cites W2912848494 @default.
• W3113175062 cites W2915422452 @default.
• W3113175062 cites W2945203964 @default.
• W3113175062 cites W2947131379 @default.
• W3113175062 cites W2960943033 @default.
• W3113175062 cites W2983296397 @default.
• W3113175062 cites W2990386108 @default.
• W3113175062 cites W3006921908 @default.
• W3113175062 cites W3010719773 @default.
• W3113175062 doi "https://doi.org/10.3892/or.2020.7890" @default.
• W3113175062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7757093" @default.
• W3113175062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33416177" @default.
• W3113175062 hasPublicationYear "2020" @default.
• W3113175062 type Work @default.
• W3113175062 sameAs 3113175062 @default.
• W3113175062 citedByCount "28" @default.
• W3113175062 countsByYear W31131750622021 @default.
• W3113175062 countsByYear W31131750622022 @default.
• W3113175062 countsByYear W31131750622023 @default.
• W3113175062 crossrefType "journal-article" @default.
• W3113175062 hasAuthorship W3113175062A5017530435 @default.
• W3113175062 hasAuthorship W3113175062A5018148936 @default.
• W3113175062 hasAuthorship W3113175062A5023755501 @default.
• W3113175062 hasAuthorship W3113175062A5024727288 @default.
• W3113175062 hasAuthorship W3113175062A5038694564 @default.
• W3113175062 hasAuthorship W3113175062A5057063084 @default.
• W3113175062 hasAuthorship W3113175062A5064657543 @default.
• W3113175062 hasAuthorship W3113175062A5071773009 @default.
• W3113175062 hasAuthorship W3113175062A5083019914 @default.
• W3113175062 hasAuthorship W3113175062A5085661325 @default.
• W3113175062 hasAuthorship W3113175062A5087055335 @default.
• W3113175062 hasBestOaLocation W31131750621 @default.
• W3113175062 hasConcept C104317684 @default.
• W3113175062 hasConcept C107846503 @default.
• W3113175062 hasConcept C121608353 @default.
• W3113175062 hasConcept C127561419 @default.
• W3113175062 hasConcept C2779013556 @default.
• W3113175062 hasConcept C2779256057 @default.
• W3113175062 hasConcept C2781018059 @default.
• W3113175062 hasConcept C29537977 @default.
• W3113175062 hasConcept C502942594 @default.
• W3113175062 hasConcept C526805850 @default.
• W3113175062 hasConcept C54355233 @default.
• W3113175062 hasConcept C55493867 @default.
• W3113175062 hasConcept C62478195 @default.
• W3113175062 hasConcept C86554907 @default.
• W3113175062 hasConcept C86803240 @default.
• W3113175062 hasConcept C95444343 @default.
• W3113175062 hasConcept C98490376 @default.
• W3113175062 hasConceptScore W3113175062C104317684 @default.
• W3113175062 hasConceptScore W3113175062C107846503 @default.
• W3113175062 hasConceptScore W3113175062C121608353 @default.
• W3113175062 hasConceptScore W3113175062C127561419 @default.
• W3113175062 hasConceptScore W3113175062C2779013556 @default.
• W3113175062 hasConceptScore W3113175062C2779256057 @default.
• W3113175062 hasConceptScore W3113175062C2781018059 @default.

• next