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- W3124210009 abstract "Immune privilege (IP), a term introduced to explain the unpredicted acceptance of allogeneic grafts by the eye and the brain, is considered a unique property of these tissues. However, immune responses are modified by the tissue in which they occur, most of which possess IP to some degree. The eye therefore displays a spectrum of IP because it comprises several tissues. IP as originally conceived can only apply to the retina as it contains few tissue-resident bone-marrow derived myeloid cells and is immunologically shielded by a sophisticated barrier – an inner vascular and an outer epithelial barrier at the retinal pigment epithelium. The vascular barrier comprises the vascular endothelium and the glia limitans. Immune cells do not cross the blood-retinal barrier (BRB) despite two-way transport of interstitial fluid, governed by tissue oncotic pressure. The BRB, and the blood-brain barrier (BBB) mature in the neonatal period under signals from the expanding microbiome and by 18 months are fully established. However, the adult eye is susceptible to intraocular inflammation (uveitis; frequency ~200/100,000 population). Uveitis involving the retinal parenchyma (posterior uveitis, PU) breaches IP, while IP is essentially irrelevant in inflammation involving the ocular chambers, uveal tract and ocular coats (anterior/intermediate uveitis/sclerouveitis, AU). Infections cause ~50% cases of AU and PU but infection may also underlie the pathogenesis of immune-mediated “non-infectious” uveitis. Dysbiosis accompanies the commonest form, HLA-B27–associated AU, while latent infections underlie BRB breakdown in PU. This review considers the pathogenesis of uveitis in the context of IP, infection, environment, and the microbiome." @default.
- W3124210009 created "2021-02-01" @default.
- W3124210009 creator A5002210515 @default.
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- W3124210009 creator A5068977275 @default.
- W3124210009 creator A5070354472 @default.
- W3124210009 date "2021-01-25" @default.
- W3124210009 modified "2023-10-17" @default.
- W3124210009 title "Immune Privilege: The Microbiome and Uveitis" @default.
- W3124210009 cites W1035124270 @default.
- W3124210009 cites W1494813615 @default.
- W3124210009 cites W1515023627 @default.
- W3124210009 cites W1518943477 @default.
- W3124210009 cites W1536027939 @default.
- W3124210009 cites W1574681462 @default.
- W3124210009 cites W1604686839 @default.
- W3124210009 cites W1692972455 @default.
- W3124210009 cites W1761622267 @default.
- W3124210009 cites W1880955151 @default.
- W3124210009 cites W1913779731 @default.
- W3124210009 cites W1918237073 @default.
- W3124210009 cites W1941562583 @default.
- W3124210009 cites W1950251394 @default.
- W3124210009 cites W1959461915 @default.
- W3124210009 cites W1959742141 @default.
- W3124210009 cites W1966161103 @default.
- W3124210009 cites W1966226308 @default.
- W3124210009 cites W1966686602 @default.
- W3124210009 cites W1969403260 @default.
- W3124210009 cites W1971803319 @default.
- W3124210009 cites W1972673579 @default.
- W3124210009 cites W1976309937 @default.
- W3124210009 cites W1976590223 @default.
- W3124210009 cites W1979898083 @default.
- W3124210009 cites W1986246471 @default.
- W3124210009 cites W1986554932 @default.
- W3124210009 cites W1986913568 @default.
- W3124210009 cites W1993804685 @default.
- W3124210009 cites W1997972850 @default.
- W3124210009 cites W2001499761 @default.
- W3124210009 cites W2003487907 @default.
- W3124210009 cites W2004633497 @default.
- W3124210009 cites W2004714320 @default.
- W3124210009 cites W2009171929 @default.
- W3124210009 cites W2009193838 @default.
- W3124210009 cites W2009525982 @default.
- W3124210009 cites W2010730265 @default.
- W3124210009 cites W2011473151 @default.
- W3124210009 cites W2014881502 @default.
- W3124210009 cites W2015242140 @default.
- W3124210009 cites W2018066285 @default.
- W3124210009 cites W2019453607 @default.
- W3124210009 cites W2021320487 @default.
- W3124210009 cites W2025425706 @default.
- W3124210009 cites W2029645821 @default.
- W3124210009 cites W2034060753 @default.
- W3124210009 cites W2045119680 @default.
- W3124210009 cites W2046869790 @default.
- W3124210009 cites W2047763108 @default.
- W3124210009 cites W2049448291 @default.
- W3124210009 cites W2050713475 @default.
- W3124210009 cites W2051373931 @default.
- W3124210009 cites W2058345140 @default.
- W3124210009 cites W2058722090 @default.
- W3124210009 cites W2062714111 @default.
- W3124210009 cites W2063516590 @default.
- W3124210009 cites W2065222875 @default.
- W3124210009 cites W2068089195 @default.
- W3124210009 cites W2070002280 @default.
- W3124210009 cites W2074295723 @default.
- W3124210009 cites W2077450760 @default.
- W3124210009 cites W2078781365 @default.
- W3124210009 cites W2084503760 @default.
- W3124210009 cites W2084627599 @default.
- W3124210009 cites W2085065264 @default.
- W3124210009 cites W2091536187 @default.
- W3124210009 cites W2092353121 @default.
- W3124210009 cites W2093455511 @default.
- W3124210009 cites W2093887564 @default.
- W3124210009 cites W2093988691 @default.
- W3124210009 cites W2094601991 @default.
- W3124210009 cites W2095555740 @default.
- W3124210009 cites W2102572577 @default.
- W3124210009 cites W2105591467 @default.
- W3124210009 cites W2106693567 @default.
- W3124210009 cites W2108393782 @default.
- W3124210009 cites W2109113634 @default.
- W3124210009 cites W2110389012 @default.
- W3124210009 cites W2111487392 @default.
- W3124210009 cites W2111731663 @default.
- W3124210009 cites W2112266897 @default.
- W3124210009 cites W2115717665 @default.
- W3124210009 cites W2121080857 @default.
- W3124210009 cites W2121990446 @default.
- W3124210009 cites W2122398832 @default.
- W3124210009 cites W2124828627 @default.
- W3124210009 cites W2126657409 @default.
- W3124210009 cites W2126847824 @default.
- W3124210009 cites W2127197214 @default.