FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128791816> ?p ?o ?g. }

• W3128791816 abstract "Our previous study showed that adhesion molecule with immunoglobulin like domain 2 (AMIGO2) is a pivotal driver gene of liver metastasis via regulating tumor cell adhesion to liver endothelial cells in mouse models. The aim of the present study was to clarify the role of AMIGO2 in liver metastasis in patients the colorectal cancer (CRC). Two human CRC cell lines, Caco‑2 (AMIGO2‑low) and HCT116 (AMIGO2‑high), were used in this study. AMIGO2‑overexpressing Caco‑2 and AMIGO2‑knockdown HCT116 cells were generated by transfection with an AMIGO2 expression vector or AMIGO2 small interfering RNA, respectively. Cell proliferation, invasion and adhesion to human liver endothelial cells were examined in <em>in vitro</em> studies. Immunohistochemical analysis was also performed to evaluate the association between AMIGO2 expression and liver metastasis in patients with CRC. <em>In vitro</em> studies revealed that cell proliferation, invasion and adhesion to liver endothelial cells were accelerated by upregulation of AMIGO2 expression, but suppressed by downregulation of AMIGO2 expression in human CRC cells. Immunohistochemical analysis using clinical CRC specimens revealed that AMIGO2 expression was associated with the frequency of liver metastasis (P<0.01), but not that of pulmonary metastasis (P=0.611) and peritoneal dissemination (P=0.909). In addition, AMIGO2 expression levels in tumor cells were significantly higher in liver metastatic foci than primary lesions (P=0.012). In conclusion, the present results indicated that AMIGO2 expression may contribute to the formation of liver metastasis in CRC." @default.
• W3128791816 created "2021-02-15" @default.
• W3128791816 creator A5005427988 @default.
• W3128791816 creator A5016665259 @default.
• W3128791816 creator A5026424733 @default.
• W3128791816 creator A5033310099 @default.
• W3128791816 creator A5039588117 @default.
• W3128791816 creator A5040453545 @default.
• W3128791816 creator A5042666949 @default.
• W3128791816 creator A5044979361 @default.
• W3128791816 creator A5051112398 @default.
• W3128791816 creator A5054108986 @default.
• W3128791816 creator A5058588600 @default.
• W3128791816 creator A5067102189 @default.
• W3128791816 creator A5067197714 @default.
• W3128791816 creator A5076427318 @default.
• W3128791816 date "2021-02-10" @default.
• W3128791816 modified "2023-09-28" @default.
• W3128791816 title "AMIGO2 as a novel indicator of liver metastasis in patients with colorectal cancer" @default.
• W3128791816 cites W1970843783 @default.
• W3128791816 cites W2002982210 @default.
• W3128791816 cites W2027823805 @default.
• W3128791816 cites W2151949105 @default.
• W3128791816 cites W2167617184 @default.
• W3128791816 cites W2476795335 @default.
• W3128791816 cites W2580140529 @default.
• W3128791816 cites W2592199419 @default.
• W3128791816 cites W2768396957 @default.
• W3128791816 cites W2770829476 @default.
• W3128791816 cites W2809263650 @default.
• W3128791816 cites W2917837889 @default.
• W3128791816 cites W2921967515 @default.
• W3128791816 cites W393131535 @default.
• W3128791816 cites W1994310095 @default.
• W3128791816 doi "https://doi.org/10.3892/ol.2021.12539" @default.
• W3128791816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7905583" @default.
• W3128791816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33732354" @default.
• W3128791816 hasPublicationYear "2021" @default.
• W3128791816 type Work @default.
• W3128791816 sameAs 3128791816 @default.
• W3128791816 citedByCount "7" @default.
• W3128791816 countsByYear W31287918162022 @default.
• W3128791816 countsByYear W31287918162023 @default.
• W3128791816 crossrefType "journal-article" @default.
• W3128791816 hasAuthorship W3128791816A5005427988 @default.
• W3128791816 hasAuthorship W3128791816A5016665259 @default.
• W3128791816 hasAuthorship W3128791816A5026424733 @default.
• W3128791816 hasAuthorship W3128791816A5033310099 @default.
• W3128791816 hasAuthorship W3128791816A5039588117 @default.
• W3128791816 hasAuthorship W3128791816A5040453545 @default.
• W3128791816 hasAuthorship W3128791816A5042666949 @default.
• W3128791816 hasAuthorship W3128791816A5044979361 @default.
• W3128791816 hasAuthorship W3128791816A5051112398 @default.
• W3128791816 hasAuthorship W3128791816A5054108986 @default.
• W3128791816 hasAuthorship W3128791816A5058588600 @default.
• W3128791816 hasAuthorship W3128791816A5067102189 @default.
• W3128791816 hasAuthorship W3128791816A5067197714 @default.
• W3128791816 hasAuthorship W3128791816A5076427318 @default.
• W3128791816 hasBestOaLocation W31287918161 @default.
• W3128791816 hasConcept C104317684 @default.
• W3128791816 hasConcept C121608353 @default.
• W3128791816 hasConcept C126322002 @default.
• W3128791816 hasConcept C127561419 @default.
• W3128791816 hasConcept C142724271 @default.
• W3128791816 hasConcept C1491633281 @default.
• W3128791816 hasConcept C16224149 @default.
• W3128791816 hasConcept C173396325 @default.
• W3128791816 hasConcept C203014093 @default.
• W3128791816 hasConcept C204232928 @default.
• W3128791816 hasConcept C2776231280 @default.
• W3128791816 hasConcept C2778019345 @default.
• W3128791816 hasConcept C2779013556 @default.
• W3128791816 hasConcept C2781018059 @default.
• W3128791816 hasConcept C29537977 @default.
• W3128791816 hasConcept C502942594 @default.
• W3128791816 hasConcept C526805850 @default.
• W3128791816 hasConcept C54009773 @default.
• W3128791816 hasConcept C54355233 @default.
• W3128791816 hasConcept C55493867 @default.
• W3128791816 hasConcept C67082663 @default.
• W3128791816 hasConcept C71924100 @default.
• W3128791816 hasConcept C81885089 @default.
• W3128791816 hasConcept C85789140 @default.
• W3128791816 hasConcept C86803240 @default.
• W3128791816 hasConceptScore W3128791816C104317684 @default.
• W3128791816 hasConceptScore W3128791816C121608353 @default.
• W3128791816 hasConceptScore W3128791816C126322002 @default.
• W3128791816 hasConceptScore W3128791816C127561419 @default.
• W3128791816 hasConceptScore W3128791816C142724271 @default.
• W3128791816 hasConceptScore W3128791816C1491633281 @default.
• W3128791816 hasConceptScore W3128791816C16224149 @default.
• W3128791816 hasConceptScore W3128791816C173396325 @default.
• W3128791816 hasConceptScore W3128791816C203014093 @default.
• W3128791816 hasConceptScore W3128791816C204232928 @default.
• W3128791816 hasConceptScore W3128791816C2776231280 @default.
• W3128791816 hasConceptScore W3128791816C2778019345 @default.
• W3128791816 hasConceptScore W3128791816C2779013556 @default.
• W3128791816 hasConceptScore W3128791816C2781018059 @default.
• W3128791816 hasConceptScore W3128791816C29537977 @default.
• W3128791816 hasConceptScore W3128791816C502942594 @default.

• next