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• W3129121588 endingPage "121732" @default.
• W3129121588 startingPage "121732" @default.
• W3129121588 abstract "This review illustrates the potential development and delivery of the organometallic half sandwiched RutheniumII arene complexes using carrier protein human serum albumin (HSA) for the selective delivery in the cancer regimes. To date many multitargeted half sandwiched RuII–arene complexes were rationally designed by the scientists either by modifying the aromatic unit or altering the chelating ligands that can enhance the selectivity or alter significant biological systems to optimize their chemotherapeutic potential. However, the half sandwiched RuII–arene complexes were designed by researchers keeping in mind the use of carrier vehicle HSA since they are relatively scarce in the literature. Hence in this review, we have discussed many examples of drug complexes that interact strongly with HSA which helps in the accumulation of the complexes inside the tumor cells through the EPR (enhanced permeability and retention) effect. Furthermore, the possible mechanisms of action of these half sandwiched RuII–arene complexes were also discussed after their selective delivery inside the cancer cells. We hope that multitargeted half sandwiched RuII–arene covered in this review will help the researcher's in the future development of new effective organometallic RuII drugs using HSA as a platform for the free selective delivery inside tumor cells." @default.
• W3129121588 created "2021-02-15" @default.
• W3129121588 creator A5015637223 @default.
• W3129121588 creator A5078531660 @default.
• W3129121588 date "2021-04-01" @default.
• W3129121588 modified "2023-09-27" @default.
• W3129121588 title "Half sandwiched RutheniumII complexes: En Route towards the targeted delivery by Human Serum Albumin (HSA)" @default.
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