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• W3129679786 abstract "Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expression in several cancer cell lines has been widely discussed in the literature, and recent work established a link between NNMT expression and metabolic diseases. Here we describe our approach to identify potent small molecule inhibitors of NNMT featuring different binding modes as elucidated by X-ray crystallographic studies." @default.
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• W3129679786 date "2021-02-13" @default.
• W3129679786 modified "2023-09-23" @default.
• W3129679786 title "Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders" @default.
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• W3129679786 doi "https://doi.org/10.3390/molecules26040991" @default.
• W3129679786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7918612" @default.
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