Matches in SemOpenAlex for { <https://semopenalex.org/work/W3131079086> ?p ?o ?g. }
- W3131079086 abstract "Obesity cardiomyopathy increases the risk of heart failure and death. Obesity is curable, leading to the restoration of the heart phenotype, but it is not clear if there are any after-effects of obesity present after weight loss. We characterize the proteomic landscape of obesity cardiomyopathy with an evaluation of whether the cardiac phenotype is still shaped after weight loss. Cardiomyopathy was validated by cardiac hypertrophy, fibrosis, oversized myocytes, and mTOR upregulation in a rat model of cafeteria diet-induced developmental obesity. By global proteomic techniques (LC-MS/MS) a plethora of molecular changes was observed in the heart and circulation of obese animals, suggesting abnormal utilization of metabolic substrates. This was confirmed by increased levels of cardiac ACSL-1, a key enzyme for fatty acid degradation and decreased GLUT-1, a glucose transporter in obese rats. Calorie restriction and weight loss led to the normalization of the heart's size, but fibrosis was still excessive. The proteomic compositions of cardiac tissue and plasma were different after weight loss as compared to control. In addition to morphological consequences, obesity cardiomyopathy involves many proteomic changes. Weight loss provides for a partial repair of the heart's architecture, but the trace of fibrotic deposition and proteomic alterations may occur." @default.
- W3131079086 created "2021-03-01" @default.
- W3131079086 creator A5019337660 @default.
- W3131079086 creator A5023166936 @default.
- W3131079086 creator A5042089708 @default.
- W3131079086 creator A5065997153 @default.
- W3131079086 creator A5068554625 @default.
- W3131079086 creator A5084619441 @default.
- W3131079086 date "2021-02-24" @default.
- W3131079086 modified "2023-10-18" @default.
- W3131079086 title "Proteomic and Structural Manifestations of Cardiomyopathy in Rat Models of Obesity and Weight Loss" @default.
- W3131079086 cites W1545311001 @default.
- W3131079086 cites W175679200 @default.
- W3131079086 cites W1910630598 @default.
- W3131079086 cites W1915149888 @default.
- W3131079086 cites W1930837752 @default.
- W3131079086 cites W1934007967 @default.
- W3131079086 cites W1965498876 @default.
- W3131079086 cites W1971107230 @default.
- W3131079086 cites W1971654402 @default.
- W3131079086 cites W1982703569 @default.
- W3131079086 cites W1984645774 @default.
- W3131079086 cites W1985905942 @default.
- W3131079086 cites W1986030239 @default.
- W3131079086 cites W1986375719 @default.
- W3131079086 cites W1989658063 @default.
- W3131079086 cites W2001738812 @default.
- W3131079086 cites W2005160887 @default.
- W3131079086 cites W2006084011 @default.
- W3131079086 cites W2009752331 @default.
- W3131079086 cites W2009773656 @default.
- W3131079086 cites W2014466762 @default.
- W3131079086 cites W2025555937 @default.
- W3131079086 cites W2031409823 @default.
- W3131079086 cites W2031680626 @default.
- W3131079086 cites W2032897242 @default.
- W3131079086 cites W2045291897 @default.
- W3131079086 cites W2048562332 @default.
- W3131079086 cites W2048583819 @default.
- W3131079086 cites W2054933011 @default.
- W3131079086 cites W2056163657 @default.
- W3131079086 cites W2074890096 @default.
- W3131079086 cites W2078598863 @default.
- W3131079086 cites W2085526580 @default.
- W3131079086 cites W2088891915 @default.
- W3131079086 cites W2090030503 @default.
- W3131079086 cites W2091169722 @default.
- W3131079086 cites W2092136583 @default.
- W3131079086 cites W2095553519 @default.
- W3131079086 cites W2099562966 @default.
- W3131079086 cites W2103291638 @default.
- W3131079086 cites W2104992254 @default.
- W3131079086 cites W2106620894 @default.
- W3131079086 cites W2109360124 @default.
- W3131079086 cites W2109673025 @default.
- W3131079086 cites W2112357770 @default.
- W3131079086 cites W2115147488 @default.
- W3131079086 cites W2123230889 @default.
- W3131079086 cites W2125392951 @default.
- W3131079086 cites W2126181836 @default.
- W3131079086 cites W2127159671 @default.
- W3131079086 cites W2133465414 @default.
- W3131079086 cites W2139500689 @default.
- W3131079086 cites W2141078657 @default.
- W3131079086 cites W2144828216 @default.
- W3131079086 cites W2145416516 @default.
- W3131079086 cites W2152065725 @default.
- W3131079086 cites W2153423299 @default.
- W3131079086 cites W2158217645 @default.
- W3131079086 cites W2167279371 @default.
- W3131079086 cites W2170851950 @default.
- W3131079086 cites W2183587606 @default.
- W3131079086 cites W2229826078 @default.
- W3131079086 cites W2260283274 @default.
- W3131079086 cites W2346567573 @default.
- W3131079086 cites W2405485021 @default.
- W3131079086 cites W2416854880 @default.
- W3131079086 cites W2417223785 @default.
- W3131079086 cites W2582219435 @default.
- W3131079086 cites W2735307121 @default.
- W3131079086 cites W2744044042 @default.
- W3131079086 cites W2745166395 @default.
- W3131079086 cites W2752408109 @default.
- W3131079086 cites W2753659515 @default.
- W3131079086 cites W2756329145 @default.
- W3131079086 cites W2762383102 @default.
- W3131079086 cites W2762689525 @default.
- W3131079086 cites W2782691474 @default.
- W3131079086 cites W2783821648 @default.
- W3131079086 cites W2790337982 @default.
- W3131079086 cites W2791078538 @default.
- W3131079086 cites W2808184177 @default.
- W3131079086 cites W2883226358 @default.
- W3131079086 cites W2886959475 @default.
- W3131079086 cites W2888814360 @default.
- W3131079086 cites W2890833873 @default.
- W3131079086 cites W2902708581 @default.
- W3131079086 cites W2908249173 @default.
- W3131079086 cites W2911867504 @default.
- W3131079086 cites W2938801784 @default.