Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133621079> ?p ?o ?g. }
- W3133621079 abstract "Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networks (GRNs) remains a major challenge. Here, we use a well-defined synthetic GRN to study in Escherichia coli how network phenotypes depend on local genetic context, i.e. the genetic neighborhood of a transcription factor and its relative position. We show that one GRN with fixed topology can display not only quantitatively but also qualitatively different phenotypes, depending solely on the local genetic context of its components. Transcriptional read-through is the main molecular mechanism that places one transcriptional unit (TU) within two separate regulons without the need for complex regulatory sequences. We propose that relative order of individual TUs, with its potential for combinatorial complexity, plays an important role in shaping phenotypes of GRNs." @default.
- W3133621079 created "2021-03-15" @default.
- W3133621079 creator A5011677727 @default.
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- W3133621079 creator A5047011809 @default.
- W3133621079 creator A5063189311 @default.
- W3133621079 creator A5064940402 @default.
- W3133621079 creator A5073758596 @default.
- W3133621079 date "2021-03-08" @default.
- W3133621079 modified "2023-10-18" @default.
- W3133621079 title "Local genetic context shapes the function of a gene regulatory network" @default.
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