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• W3135433679 endingPage "1243" @default.
• W3135433679 startingPage "1234" @default.
• W3135433679 abstract "Cellular immunotherapeutic approaches such as chimeric antigen receptor (CAR) T-cell therapy in chronic lymphocytic leukemia (CLL) thus far have not met the high expectations. Therefore it is essential to better understand the molecular mechanisms of CLLinduced T-cell dysfunction. Even though a significant number of studies are available on T-cell function and dysfunction in CLL patients, none examine dysfunction at the epigenomic level. In non-malignant T-cell research, epigenomics is widely employed to define the differentiation pathway into T-cell exhaustion. Additionally, metabolic restrictions in the tumor microenvironment that cause T-cell dysfunction are often mediated by epigenetic changes. With this review paper we argue that understanding the epigenetic (dys)regulation in T cells of CLL patients should be leveled to the knowledge we currently have of the neoplastic B cells themselves. This will permit a complete understanding of how these immune cell interactions regulate T- and B-cell function. Here we relate the cellular and phenotypic characteristics of CLL-induced T-cell dysfunction to epigenetic studies of T-cell regulation emerging from chronic viral infection and tumor models. This paper proposes a framework for future studies into the epigenetic regulation of CLL-induced Tcell dysfunction, knowledge that will help to guide improvements in the utility of autologous T-cell based therapies in CLL." @default.
• W3135433679 created "2021-03-15" @default.
• W3135433679 creator A5011746128 @default.
• W3135433679 creator A5064164625 @default.
• W3135433679 creator A5076849841 @default.
• W3135433679 creator A5091486815 @default.
• W3135433679 date "2021-03-11" @default.
• W3135433679 modified "2023-10-16" @default.
• W3135433679 title "T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective" @default.
• W3135433679 cites W1243376384 @default.
• W3135433679 cites W1429374962 @default.
• W3135433679 cites W1504853565 @default.
• W3135433679 cites W1907569406 @default.
• W3135433679 cites W1963522404 @default.
• W3135433679 cites W1967190902 @default.
• W3135433679 cites W1975706139 @default.
• W3135433679 cites W1981472067 @default.
• W3135433679 cites W1985182657 @default.
• W3135433679 cites W1985499930 @default.
• W3135433679 cites W2001710477 @default.
• W3135433679 cites W2005484484 @default.
• W3135433679 cites W2015415347 @default.
• W3135433679 cites W2018768806 @default.
• W3135433679 cites W2019035778 @default.
• W3135433679 cites W2020586896 @default.
• W3135433679 cites W2025741975 @default.
• W3135433679 cites W2027699534 @default.
• W3135433679 cites W2037198742 @default.
• W3135433679 cites W2042031631 @default.
• W3135433679 cites W2042699075 @default.
• W3135433679 cites W2046317156 @default.
• W3135433679 cites W2049884015 @default.
• W3135433679 cites W2051763289 @default.
• W3135433679 cites W2088373095 @default.
• W3135433679 cites W2092345398 @default.
• W3135433679 cites W2099944032 @default.
• W3135433679 cites W2109560454 @default.
• W3135433679 cites W2119319172 @default.
• W3135433679 cites W2119896120 @default.
• W3135433679 cites W2122792339 @default.
• W3135433679 cites W2135215267 @default.
• W3135433679 cites W2164164239 @default.
• W3135433679 cites W2165772661 @default.
• W3135433679 cites W2204986825 @default.
• W3135433679 cites W2277625008 @default.
• W3135433679 cites W2417349250 @default.
• W3135433679 cites W2478467838 @default.
• W3135433679 cites W2510890697 @default.
• W3135433679 cites W2514996992 @default.
• W3135433679 cites W2530292798 @default.
• W3135433679 cites W2541574334 @default.
• W3135433679 cites W2545009331 @default.
• W3135433679 cites W2550652857 @default.
• W3135433679 cites W2558763624 @default.
• W3135433679 cites W2560661681 @default.
• W3135433679 cites W2594333172 @default.
• W3135433679 cites W2596886590 @default.
• W3135433679 cites W2605683323 @default.
• W3135433679 cites W2742260468 @default.
• W3135433679 cites W2751789068 @default.
• W3135433679 cites W2792012959 @default.
• W3135433679 cites W2797429263 @default.
• W3135433679 cites W2889555301 @default.
• W3135433679 cites W2889763022 @default.
• W3135433679 cites W2894023013 @default.
• W3135433679 cites W2899145148 @default.
• W3135433679 cites W2903754922 @default.
• W3135433679 cites W2906204636 @default.
• W3135433679 cites W2910079519 @default.
• W3135433679 cites W2913094775 @default.
• W3135433679 cites W2933481367 @default.
• W3135433679 cites W2946801856 @default.
• W3135433679 cites W2947348310 @default.
• W3135433679 cites W2947617159 @default.
• W3135433679 cites W2948935080 @default.
• W3135433679 cites W2950413690 @default.
• W3135433679 cites W2951520325 @default.
• W3135433679 cites W2951598503 @default.
• W3135433679 cites W2952815301 @default.
• W3135433679 cites W2958308511 @default.
• W3135433679 cites W2963902956 @default.
• W3135433679 cites W2971728187 @default.
• W3135433679 cites W2972334511 @default.
• W3135433679 cites W2973024487 @default.
• W3135433679 cites W2975736685 @default.
• W3135433679 cites W2978871511 @default.
• W3135433679 cites W2979874482 @default.
• W3135433679 cites W2984631300 @default.
• W3135433679 cites W2986728550 @default.
• W3135433679 cites W2990263217 @default.
• W3135433679 cites W3000690579 @default.
• W3135433679 cites W3010312681 @default.
• W3135433679 cites W3011706914 @default.
• W3135433679 cites W3016631370 @default.
• W3135433679 cites W3020888809 @default.
• W3135433679 cites W3021153526 @default.
• W3135433679 cites W3035999666 @default.
• W3135433679 cites W3038016373 @default.

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