FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3136365296> ?p ?o ?g. }

• W3136365296 endingPage "e24827" @default.
• W3136365296 startingPage "e24827" @default.
• W3136365296 abstract "GINS subunits, a protein complex composed of GINS1, GINS2, GINS3 and GINS4 in the human genome and the expression level of each GINS subunits plays an important role in different human cancers. As one of the most common malignancies after lung cancer in the world, precise biomarkers for early diagnosis and treatment in breast cancer are important. The purpose of our study was to elucidate the expression and prognostic value of GINS subunits in breast cancer. The purpose of present study was to explore the expression level of GINS subunits in breast cancer patients. In the present study, we investigated the gene alteration, gene expression and potential prognostic value of GINS subunits by using the Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, cBioPortal, and bc-GenExMiner databases. Then, the GeneMANIA database was used to show the genes that associated with GINS subunits. Furthermore, gene ontology pathway analysis was conducted by using the Metascape database. Finally, immune infiltration analysis in GINS subunits were evaluated using the Tumor Immune Estimation Resource (TIMER) database. Our analyses demonstrated that the expression levels of different GINS subunits were different between breast cancer and normal breast tissues. The expression levels of GINS1, GINS2, and GINS4 were significantly higher in breast cancer tissues than in normal tissues. Survival analysis revealed that increased the expression levels of GINS subunits were associated with poor prognoses in all patients with breast cancer. Gene ontology pathway enrichment analysis of the GINS subunits suggested that GINS subunits involved in pathways including the cell cycle checkpoint, DNA replication and other meaningful signaling pathways. We systemically analyzed the expression, prognostic, clinicopathologic values, and potential functional networks of GINS subunits in breast cancer. Our findings showed that individual GINS subunits could be new potential prognostic biomarkers for breast cancer. However, further verification studies are still needed to prove the clinical value of GINS subunits in breast cancer patients." @default.
• W3136365296 created "2021-03-29" @default.
• W3136365296 creator A5015005766 @default.
• W3136365296 creator A5027822382 @default.
• W3136365296 creator A5043030184 @default.
• W3136365296 creator A5082594830 @default.
• W3136365296 creator A5087117149 @default.
• W3136365296 date "2021-03-19" @default.
• W3136365296 modified "2023-09-26" @default.
• W3136365296 title "Expression and prognosis analysis of GINS subunits in human breast cancer" @default.
• W3136365296 cites W1559357300 @default.
• W3136365296 cites W1611375148 @default.
• W3136365296 cites W1720310397 @default.
• W3136365296 cites W1948500848 @default.
• W3136365296 cites W1967850141 @default.
• W3136365296 cites W1970843450 @default.
• W3136365296 cites W1977408739 @default.
• W3136365296 cites W1985213868 @default.
• W3136365296 cites W1986348445 @default.
• W3136365296 cites W1990148464 @default.
• W3136365296 cites W2005871139 @default.
• W3136365296 cites W2009999911 @default.
• W3136365296 cites W2015012409 @default.
• W3136365296 cites W2017806952 @default.
• W3136365296 cites W2055182100 @default.
• W3136365296 cites W2094827087 @default.
• W3136365296 cites W2103628876 @default.
• W3136365296 cites W2127714324 @default.
• W3136365296 cites W2134156532 @default.
• W3136365296 cites W2138643693 @default.
• W3136365296 cites W2149441684 @default.
• W3136365296 cites W2166288313 @default.
• W3136365296 cites W2221837786 @default.
• W3136365296 cites W2507880739 @default.
• W3136365296 cites W2518928271 @default.
• W3136365296 cites W2607129810 @default.
• W3136365296 cites W2736730167 @default.
• W3136365296 cites W2752658156 @default.
• W3136365296 cites W2765224588 @default.
• W3136365296 cites W2809000676 @default.
• W3136365296 cites W2899774807 @default.
• W3136365296 cites W2901821687 @default.
• W3136365296 cites W2917423152 @default.
• W3136365296 cites W2928665623 @default.
• W3136365296 cites W90137025 @default.
• W3136365296 doi "https://doi.org/10.1097/md.0000000000024827" @default.
• W3136365296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7982226" @default.
• W3136365296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33725952" @default.
• W3136365296 hasPublicationYear "2021" @default.
• W3136365296 type Work @default.
• W3136365296 sameAs 3136365296 @default.
• W3136365296 citedByCount "11" @default.
• W3136365296 countsByYear W31363652962021 @default.
• W3136365296 countsByYear W31363652962022 @default.
• W3136365296 countsByYear W31363652962023 @default.
• W3136365296 crossrefType "journal-article" @default.
• W3136365296 hasAuthorship W3136365296A5015005766 @default.
• W3136365296 hasAuthorship W3136365296A5027822382 @default.
• W3136365296 hasAuthorship W3136365296A5043030184 @default.
• W3136365296 hasAuthorship W3136365296A5082594830 @default.
• W3136365296 hasAuthorship W3136365296A5087117149 @default.
• W3136365296 hasBestOaLocation W31363652961 @default.
• W3136365296 hasConcept C104317684 @default.
• W3136365296 hasConcept C121608353 @default.
• W3136365296 hasConcept C126322002 @default.
• W3136365296 hasConcept C143998085 @default.
• W3136365296 hasConcept C150194340 @default.
• W3136365296 hasConcept C18431079 @default.
• W3136365296 hasConcept C502942594 @default.
• W3136365296 hasConcept C530470458 @default.
• W3136365296 hasConcept C54355233 @default.
• W3136365296 hasConcept C60644358 @default.
• W3136365296 hasConcept C71924100 @default.
• W3136365296 hasConcept C86803240 @default.
• W3136365296 hasConceptScore W3136365296C104317684 @default.
• W3136365296 hasConceptScore W3136365296C121608353 @default.
• W3136365296 hasConceptScore W3136365296C126322002 @default.
• W3136365296 hasConceptScore W3136365296C143998085 @default.
• W3136365296 hasConceptScore W3136365296C150194340 @default.
• W3136365296 hasConceptScore W3136365296C18431079 @default.
• W3136365296 hasConceptScore W3136365296C502942594 @default.
• W3136365296 hasConceptScore W3136365296C530470458 @default.
• W3136365296 hasConceptScore W3136365296C54355233 @default.
• W3136365296 hasConceptScore W3136365296C60644358 @default.
• W3136365296 hasConceptScore W3136365296C71924100 @default.
• W3136365296 hasConceptScore W3136365296C86803240 @default.
• W3136365296 hasIssue "11" @default.
• W3136365296 hasLocation W31363652961 @default.
• W3136365296 hasLocation W31363652962 @default.
• W3136365296 hasLocation W31363652963 @default.
• W3136365296 hasLocation W31363652964 @default.
• W3136365296 hasOpenAccess W3136365296 @default.
• W3136365296 hasPrimaryLocation W31363652961 @default.
• W3136365296 hasRelatedWork W1971926891 @default.
• W3136365296 hasRelatedWork W2052655934 @default.
• W3136365296 hasRelatedWork W2053053668 @default.
• W3136365296 hasRelatedWork W2111172999 @default.
• W3136365296 hasRelatedWork W2114454856 @default.

• next