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• W3139159526 abstract "Abstract Interplay between the second messengers cAMP and Ca 2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca 2+ -sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosphorylates sites primed by PKA to bring about changes including synaptic long-term depression (LTD). AKAP79 supports signaling of this type by anchoring PKA and calcineurin in tandem. In this study, we discovered that AKAP79 increases the rate of calcineurin dephosphorylation of type II PKA regulatory subunits by an order of magnitude. Fluorescent PKA activity reporter assays, supported by kinetic modeling, show how AKAP79-enhanced calcineurin activity enables suppression of PKA without altering cAMP levels by increasing PKA catalytic subunit capture rate. Experiments with hippocampal neurons indicate that this mechanism contributes towards LTD. This non- canonical mode of PKA regulation may underlie many other cellular processes." @default.
• W3139159526 created "2021-03-29" @default.
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• W3139159526 date "2021-03-15" @default.
• W3139159526 modified "2023-10-02" @default.
• W3139159526 title "AKAP79 enables calcineurin to directly suppress protein kinase A activity" @default.
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• W3139159526 doi "https://doi.org/10.1101/2021.03.14.435320" @default.
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