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- W3139273669 abstract "Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)-restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1-specific, HLA-E-restricted T cells have not been observed in HIV-1-infected individuals. Here, HLA-E-restricted, HIV-1-specific CD8 + T cells were primed in vitro. These T cell clones and allogeneic CD8 + T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4 + T cells in vitro. Vaccine induction of efficacious HLA-E-restricted HIV-1-specific T cells should therefore be possible." @default.
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- W3139273669 date "2021-03-04" @default.
- W3139273669 modified "2023-10-14" @default.
- W3139273669 title "HLA-E–restricted, Gag-specific CD8<sup>+</sup>T cells can suppress HIV-1 infection, offering vaccine opportunities" @default.
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- W3139273669 doi "https://doi.org/10.1126/sciimmunol.abg1703" @default.
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